OBJECTIVE: The 24-hour creatinine clearance is the standard clinical technique to measure renal function; however, this measurement is cumbersome and inconvenient for patients. We hypothesized that a camera-based Tc-99m mercaptoacetyltriglycine (MAG3) clearance obtained simultaneously with a standard MAG3 scan would correlate well with the 24-hour creatinine clearance and could serve as a simpl...

We quantitatively evaluated total and individual renal function by technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renal scintigraphy before and after radiofrequency ablation (RFA) of renal tumors. Eleven patients who underwent Tc-99m MAG3 renal scintigraphy 1 week before and after RFA were evaluated (7 men and 4 women; age range: 23-83 years; mean age: 60.6 years). Five patients had soli...

background: measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. however some critical factors such as kidney depth and background counts are still troublesome in the u...

Rhemium-186-1-hydroxyethylidene-1,1-diphosphonate ((186)Re-HEDP) has been used for the palliation of metastatic bone pain. However, delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of (186)Re-HEDP. We designed, synthesized and evaluated a stable (186)Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosph...

Rhenium-186-1-hydroxyethylidene-1,1-diphosphonate (186Re-HEDP) has been used for the palliation of metastatic bone pain. Delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of (186)Re-HEDP in vivo. In this study, on the basis of the concept of bifunctional radiopharmaceuticals, we designed a stable 186Re-mercaptoacetylglycyl...

We compared single-sample methods, proposed by Russell et al. and Bubeck et al., and camera-based methods in calculating 99mTc-MAG3 clearance, and determined camera-based methods that provide estimates comparable to those measured by the Russell method. Twenty-one patients underwent 99mTc-MAG3 renal scintigraphy, and clearance was measured by the Russell method and Bubeck method. Various renogr...

OBJECTIVE The aim of this study was to demonstrate the functional compensation that occurs in kidneys which accompany a partner with total or partial loss of renal functioning mass, using camera-based Tc 99m MAG3 clearance technique. MATERIAL AND METHODS Eighty five patients (43M, 42F, age: 44.8±12.6, range: 18-77 years) with normal serum creatinine levels and normal (<Grade 1) Tc 99m MAG3 re...

Background: Measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. Gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. However some critical factors such as kidney depth and background counts are still troublesome in...

Technetium-99m MAG3, a technetium-labeled analog of hippuran, was compared with [131I] hippuran using a simultaneous dual isotope study in 20 patients. The plasma clearance for MAG3 was lower than that of hippuran, but its plasma concentration was higher, resulting in similar rates of excretion and similar renal time-activity curves. Apart from better statistics with the technetium-labeled agen...

Objective: Glomerular filtration can eliminate a substance only from the filtered fraction of the renal plasma flow. Since that fraction normally is 20%, ERPF agents clear from the kidneys about five times as fast as GFR agents. In most chronic renal diseases, the filtration fraction (GFR divided by ERPF) is largely unaffected, so the GFR can be estimated by dividing the ERPF by five. The aim o...