Macrodactyly is a rare family of congenital disorders characterized by the diffuse enlargement of 1 or more digits. Multiple tissue types within the affected digits are involved, but skeletal patterning and gross morphological features are preserved. Not all tissues are equally involved and there is marked heterogeneity with respect to clinical phenotype. The molecular mechanisms responsible fo...

Macrodactyly is a discrete congenital anomaly consisting of enlargement of all tissues localized to the terminal portions of a limb, typically within a 'nerve territory'. The classic terminology for this condition is 'lipofibromatous hamartoma of nerve' or Type I macrodactyly. The peripheral nerve, itself, is enlarged both in circumference and in length. It is not related to neurofibromatosis (...

We report the results of the treatment of 23 patients with macrodactyly. Eighteen had a two-stage bulk-reducing (defatting) procedure; phalangectomy was used to shorten the digits. At a mean follow-up of nine years (2 to 12), two patients had been lost to follow-up, and three await a second-stage procedure. Good cosmetic correction was achieved in 12 patients, with satisfactory results in seven...

Macrodactyly represents a rare congenital anomaly characterized by distal limb overgrowth of all tissue elements. This should be distinguished from secondary digital/limb enlargement that occurs in vascular anomalies or as a result of other syndromes. Macrodactyly is defined by an elargement of all the structures of fingers or toes and characterized by hypertrophy of the bones and surrounding s...

Congenital macrodactyly is a rare congenital malformation characterised by progressive enlargement of all mesenchymal elements of a digit. The present study is an attempt to draw the attention towards the similarities and differences between macrodactyly of the hand and foot. Radiographical, operative findings and histopathological examination of five cases are included in the present study. Em...

Figure 1. Asymmetric hypertrophy of the left arm and in particular the left first and second digit macrodactyly.

PURPOSE We evaluated the result of a combined single-stage surgery in the treatment of first ray macrodactyly in children. INTRODUCTION Macrodactyly is a rare congenital abnormality that involves thickening of both the soft tissue and bone of the affected digits. It is more frequent in fingers than toes, where there is less neural involvement. Increased growth is also seen in neurofibromatosi...

Fibrolipomatous hamartomas are rare benign nerve tumors caused by a proliferation of fibroadipose tissue within the perineurium and endoneurium peripheral nerves. They often present during first second decades life with progressive neuritic symptoms regularly associated territory overgrowth, or macrodactyly, as well development exostoses. These missed clinical exam due to lack recognition sympt...