The effect of oral treatment of rats for 12 days with the contraceptive steroids, mestranol (0\m=.\08mg/rat/day) and lynoestrenol (2\m=.\5mg/rat/day) alone and in combination, on ovarian histamine content was studied. All treatments resulted in a decrease in the histamine content per ovary, but this was only significant for mestranol alone. When the results were expressed in terms of histamine ...

Apolipoprotein E (apoE) is the major lipid carrier in the central nervous system. As apoE plays a major role in the pathogenesis of Alzheimer disease (AD) and also mediates repair pathways after several forms of acute brain injury, modulating the expression, secretion, or function of apoE may provide potential therapeutic approaches for several neurological disorders. Here we show that progeste...

lynestrenol 0.5 mg.(exlution) given to patients orally from the first day of their cycle in a continuous manner suppressed cervical mucorrhea and spinbarkeit sufficiently ennough to stop sperm penetration to the cervical canal. fern reactions were mostly negative and all post- coital examinations (sims huhner tests) showed an absence of spermatozoa.

Six women with normal menstrual cycles were treated over six cycles with Fysioquens, a normophasic contraceptive consisting of 7 tablets of ethinyloestradiol (EE) 0-050 mg and 15 tablets containing 1-0 mg lynestrenol + 0-050 mg EE. In the 1st, 3rd and 6th treatment cycles and in the cycles before and after treatment, hormonal assays and other tests were carried out to determine whether ovulatio...

SYNOPSIS Samples of vaginal secretions of 'normal' women were examined over a period of up to two years. Patients with asymptomatic candidiasis on one occasion were more likely to have Candida albicans again when sampled a year later than were women with no yeasts on the first occasion. This principle applied also to /3-haemolytic streptococci of Lancefield's groups B and D. There was no signif...

AIM Fibrocystic mastosis (FCM) is the most frequent benign breast lesion. Most treatments for fibrocystic mastosis are: hormonl, with beneficial results and non-hormonal, with fluctuating results. MATERIAL AND METHODS A number of 210 cases were studied, which were divided into 7 groups. The study lasted for 9 months and it was carried out on the basis of a personal examination sheet. The foll...

Of 261 women who completed a self-rating scale for measuring depression, 168 were taking oral contraceptives and 93 were using physical methods of contraception. Of the group of women taking oral contraceptives 6.6% were more severely depressed than any of the control group. There was a significant variation in the depth of depression related to the day of the menstrual cycle in the control gro...