Background: Chemotherapy plays a very important role in the treatment of leukemia but the resistance properties of the lymphoblasts limit the effect of chemotherapy. One of the main mechanisms of resistance to chemotherapy is the increased expression of MDR1 gene. The aim of this study was to explore the effect of resveratrol on the expression of MDR1 gene in leukemic lymphoblast of new...

background: chemotherapy plays a very important role in the treatment of leukemia but the resistance properties of the lymphoblasts limit the effect of chemotherapy. one of the main mechanisms of resistance to chemotherapy is the increased expression of mdr1 gene. the aim of this study was to explore the effect of resveratrol on the expression of mdr1 gene in leukemic lymphoblast of new cases o...

Lymphoblasts from 36 children with acute lymphocytic leukemia and two children with convoluted lymphoma were evaluated for expression of membrane receptors for sheep erythrocytes, complement, and the Fc portion of immunoglobulin G as well as for surface membrane immunoglobulin. Thirty patients had lymphoblasts that failed to express these membrane markers, four patients had sheep erythrocyte re...

Intracellular adenosine formation and release to extracellular space was studied in WI-L2-B and SupT1-T lymphoblasts under conditions which induce or do not induce ATP catabolism. Under induced conditions, B lymphoblasts but not T lymphoblasts, release significant amounts of adenosine, which are markedly elevated by adenosine deaminase inhibitors. In T lymphoblasts, under induced conditions, on...

Objective:The objective of this study is to determine the frequency pancytopenia and bone marrow response treatment acute lymphoblastic leukemia. Materials And Methods:This a cross sectional carried out at Medical Oncology Department, Hayatabad Complex, Peshawar. A total 120 patients were included in study. Venous blood sample was obtained from sent laboratory hospital for assessment red cells,...

cultured lymphoblasts required physical contact with responding lymphocytes to induce transformiiation. In quantitative terms, lymphocytes incorporate as much thymidine when,mixed with irradiated cultured lymphoblasts as they (lo in response to l)hytolhenma-glutin1in. The stimulation of lymphocyte transformation by allogeneic cultured lymphoblasts did not parallel the stimulation of lymphocyte ...

A Hodgkin cell-specific antigen detected by the monoclonal antibody Ki-1 was found on T helper lymphocytes after activation by autologous and allogeneic stimulator cells. About 50% of lymphoblasts generated by autoand alloactivation reacted with the antibody. In contrast. only less than 6% of lymphoblasts stimulated with Con-A. phytohemagglutinin (PHA). or protein A. and none of lymphoblasts

BACKGROUND Familial breast cancer is associated with mutations in several genes (BRCA1, BRCA2, p53, ATM) whose protein products protect against radiation-induced genotoxicity. This study tested whether sporadic breast cancer was associated with constitutive radiation hypersensitivity. METHODS Blood lymphocytes and EBV-transformed lymphoblasts from patients with newly diagnosed breast cancer a...

We determined the prognostic importance of morphologically identifiable persistent disease at day 15 and days 22 to 25 of remission induction in childhood acute lymphoblastic leukemia (ALL). Among 546 patients entered on 2 consecutive protocols, 397 patients had evaluable bone marrow (BM) examinations on day 15 (+/- 1 day) and 218 on days 22 to 25 (+/- 1 day). Fifty-seven patients (14%) had per...

We determined the prognostic importance of morphologically identifiable persistent disease at day 15 and days 22 to 25 of remission induction in childhood acute lymphoblastic leukemia (ALL). Among 546 patients entered on 2 consecutive protocols, 397 patients had evaluable bone marrow (BM) examinations on day 15 ( 1 day) and 218 on days 22 to 25 ( 1 day). Fifty-seven patients (14%) had persisten...