background: acute lymphoblastic leukemia (all) is the most common form of childhood cancer leading to cancer-related death in children. most infants with all harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. mixed-lineage leukemia-rearrangement (mll-rearrange...

abstract background leukemia is the most prevalent childhood cancer and acute lymphoblastic leukemia (all) constitutes 75% of all cases. the most frequent presenting symptoms are fever, weight loss and pallor. early detection of clinical symptoms positively affects timely diagnosis. the objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune phen...

midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. herein, we describe a case of acute pre b cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. at the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. our case sugg...

acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. the conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. it has been rarely reported in the literature. in leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. herein, we rep...

Midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. Herein, we describe a case of acute pre B cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. At the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. Our case sug...

recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. to evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. the polymorphisms of genes encoding carcinogen-metabolizing ...

background : we conducted the present study to investigate the frequency of prothrombin g20210a mutation among acute lymphoblastic leukemia patients and healthy individuals from western iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population. methods : the studied groups consisted of 92 children with acute lymphoblastic le...

Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizi...

neuroblastoma is the most common extracranial solid tumor in children. the co- occurrence of neuroblastoma and acute lymphoblastic leukemia is rare. we report a rare case of advanced-stage neuroblastoma in a 3.5-year-old girl that was accompanied by acute lymphoblastic leukemia following treatment. her leukemia may have been due to chemotherapy (secondary leukemia) or may have been de novo.