نتایج جستجو برای: luminal a

تعداد نتایج: 13434237  

2017
Thomas Fleischer Jovana Klajic Miriam Ragle Aure Riku Louhimo Arne V. Pladsen Lars Ottestad Nizar Touleimat Marko Laakso Ann Rita Halvorsen Grethe I. Grenaker Alnæs Margit L.H. Riis Åslaug Helland Sampsa Hautaniemi Per Eystein Lønning Bjørn Naume Anne-Lise Børresen-Dale Jörg Tost Vessela N. Kristensen

Breast cancer patients with Luminal A disease generally have a good prognosis, but among this patient group are patients with good prognosis that are currently overtreated with adjuvant chemotherapy, and also patients that have a bad prognosis and should be given more aggressive treatment. There is no available method for subclassification of this patient group. Here we present a DNA methylatio...

Journal: :archives of breast cancer 0
hassan nosrati cancer research center, cancer institute of iran, tehran, iran hossein mozdarani department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran peyman hadad radiation oncology research center, cancer institute, tehran university of medical sciences, tehran, iran ramesh omranipour cancer research center, cancer institute of iran, tehran, iran sahar mozdarani cytogenome medical genetics laboratory, ale-ahmad highway, parvaneh street, chamran medical building, tehran, iran mohsen bakhshandeh department of radiology technology, allied health school, shahid beheshti university of medical sciences, tehran, iran

background: about 83% of patients with breast cancer (bc) undergo radiation therapy. these patients show various degrees of mild to acute reactions during and after the completion of treatment.the aim of this study was to compare inherent radiosensitivity of gamma-irradiated g0-lymphocytes between bc patients and normal individuals using cytokinesis blocked micronucleous assay. methods: three t...

2018
Maureen Joffe Oluwatosin Ayeni Shane Anthony Norris Valerie Ann McCormack Paul Ruff Ishani Das Alfred I Neugut Judith S Jacobson Herbert Cubasch

PURPOSE Reported breast cancer incidence is rising in South Africa, where some women are diagnosed late and have poor outcomes. We studied patient and provider factors associated with clinical stage at diagnosis among women diagnosed at the Chris Hani Baragwanath Academic Hospital in Soweto, Johannesburg in 2015-2016. METHODS From face-to-face interviewer-administered questionnaires we compar...

Amir Nader Emami Razavi, and Javad Tavakkoly Bazzaz, Farzaneh Darbeheshti, Mir Saeed Yekaninejad, Pantea Izadi,

Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with lu...

Journal: :basic and clinical cancer research 0
rahim akrami cancer research center, cancer institute of iran, tehran university of medical sciences, iran/ department of epidemiology & biostatistics, school of public health, tehran university of medical sciences, iran reza ghiasvand cancer research center, cancer institute of iran, tehran university of medical sciences, iran/ department of biostatistics, institute of basic medical sciences, university of oslo, oslo, norway akbar fotouhi department of epidemiology & biostatistics, school of public health, tehran university of medical sciences, iran iraj harirchi cancer research center, cancer institute of iran, tehran university of medical sciences, iran abbas rezaianzadeh research center for health sciences, department of epidemiology, school of health and nutrition, shiraz university of medical sciences, shiraz, iran abdolrasoul talei breast diseases research group, breast cancer research center , acecr

background: the etiology of breast cancer and our understanding on the carcinogenicity of different risk factors is impotant for control programms. objective: we investigated the expression of estrogen and progesterone receptors (er, pr), and human epithelial receptor 2 (her2) overexpression and its associations, with environmental risk factors among breast cancer patients.  methods: we classif...

Background & Aims: Ameloblastoma is a slow growing, locally invasive epithelial odontogenic tumor and high rate of recurrence. Mechanisms involving ameloblastoma invasiveness are poorly understood, and no definitive treatment procedures for individual variants are mentioned in the literature. Matrix metalloproteinases (MMPs) especially MMP-2 causes degradation of the matrix thereby promoting in...

Journal: :Klinische Wochenschrift 1922

2015
Federica Tomao Anselmo Papa Eleonora Zaccarelli Luigi Rossi Davide Caruso Marina Minozzi Patrizia Vici Luigi Frati Silverio Tomao

Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors. It has became apparent that this diversity may be justified by distinct patterns of genetic, epigenetic, and transcriptomic aberrations. The identification of gene-expression microarray-based characteristics has led to the identification of at...

Journal: :Breast care 2015
Hideo Shimizu Yoshiya Horimoto Atsushi Arakawa Hiroshi Sonoue Mami Kurata Taijiro Kosaka Katsuya Nakai Takanori Himuro Emi Tokuda Yuka Takahashi Fumi Taira Mayuko Ito Ikuko Abe Koji Senuma Lisette Stork-Sloots Femke de Snoo Mitsue Saito

BACKGROUND As data on using MammaPrint®, a 70-gene expression profile for molecular subtyping of breast cancer, are limited in Japanese patients, we aimed to determine the gene profiles of Japanese patients using MammaPrint and to investigate its possible clinical application for selecting adjuvant treatments. PATIENTS AND METHODS 50 women treated surgically at our institution were examined. ...

2016
Nariya Cho

During the last 15 years, traditional breast cancer classifications based on histopathology have been reorganized into the luminal A, luminal B, human epidermal growth factor receptor 2 (HER2), and basal-like subtypes based on gene expression profiling. Each molecular subtype has shown varying risk for progression, response to treatment, and survival outcomes. Research linking the imaging pheno...

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