The aim of the project was to assemble two optimum solid lipid nanoparticle (SLN) formulations for oral delivery of loperamide (LPM) to treat different types of diarrhea, and to evaluate their release profiles in vitro and pharmacokinetic properties in vivo. In this work, glyceryl trimyristate (Dynasan 114) nanoparticles containing the drug LPM and sodium cholate as a stabilizer were prepared u...

Situs-specific organogenesis in the mouse results from leftward fluid flow in the node cavity and subsequent left-sided expression of Nodal in the lateral plate mesoderm (LPM). Nodal expression at the node is essential for the subsequent asymmetric Nodal expression in the left LPM, but the precise role of Nodal produced at the node has remained unknown. We have now investigated how the Nodal si...

BACKGROUND The OxyMask(™) is a unique, open-style, oxygen mask that was originally developed in 2005. The original mask was modified, using computational fluid dynamics numerical simulations, with the goal of allowing it to produce a wider range of FiO(2). This analysis was used to guide the modification of the mask shell and the location for the oxygen diffuser. METHODS The new OxyMask was a...

The medial portion of the cat's lateral posterior-pulvinar complex (LPm) receives a prominent ascending projection from the superficial layers of the superior colliculus. This region of the thalamus has been suggested to serve as a relay by which visual information from the midbrain could be conveyed to extrastriate cortex. In order to determine how the functional organization within the LPm co...

Exogenous application of BMP to the lateral plate mesoderm (LPM) of chick embryos at the early somite stage had a positive effect on Nodal expression. BMP applications into the right LPM were followed by a rapid activation of Nodal, while applications into the left LPM resulted in expansion of the normal domain of Nodal expression. Conversely, blocking of BMP signaling by Noggin in the left LPM...

The transcription factor Foxh1 mediates Nodal signaling. The role of Foxh1 in left-right (LR) patterning was examined with mutant mice that lack this protein in lateral plate mesoderm (LPM). The mutant mice failed to express Nodal, Lefty2 and Pitx2 on the left side during embryogenesis and exhibited right isomerism. Ectopic introduction of Nodal into right LPM, by transplantation of left LPM or...

PURPOSE A local position measurement (LPM) system can accurately track the distance covered and the average speed of whole-body movements. However, for the quantification of a soccer player's workload, accelerations rather than positions or speeds are essential. The main purpose of the current study was therefore to determine the accuracy of LPM in measuring average and peak accelerations for a...

Given that the lateral plate mesoderm (LPM) gives rise to the cardiovascular system, identifying the cascade of signalling events that subdivides the LPM into distinct regions during development is an important question. Retinoic acid (RA) is known to be necessary for establishing the expression boundaries of important transcription factors that demarcate distinct regions along the anterior pos...

Empirical research on Lower Partial Moment (LPM) has ignored its portfolio algorithms and the major benefit of such analysis: that its utility function is as general as the utility function assumed by stochastic dominance analysis. Since efficient algorithms for stochastic dominance do not exist, an LPM algorithm may be a viable substitute. This paper is concerned with the composition of portfo...

Logic programs with aggregates (LP) are one of the major linguistic extensions to Logic Programming (LP). In this work, we propose a generalization of the notions of unfounded set and well-founded semantics for programs with monotone and antimonotone aggregates (LPm,a programs). In particular, we present a new notion of unfounded set for LPm,a programs, which is a sound generalization of the or...