نتایج جستجو برای: lpa

تعداد نتایج: 2310  

Lysophosphatidic acid (LPA) known as a serum-derived growth factor, is involved in several cell physiological functions in the female reproductive system including: oocyte maturation, in vitro fertilization and embryo implantation by its transmembrane G protein-coupled receptors. The aim of the present study was to examine the effect of LPA on in vitro follicular development o...

Journal: :Cancer science 2008
Tadaaki Yamada Seiji Yano Hirokazu Ogino Kenji Ikuta Soji Kakiuchi Masaki Hanibuchi Takanori Kanematsu Tetsuo Taniguchi Yoshitaka Sekido Saburo Sone

Lysophosphatidic acid (LPA) is one of the simplest natural phospholipids. This phospholipid is recognized as an extracellular potent lipid mediator with diverse effects on various cells. Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPA(1) and LPA(2), in several cancer cell lines, the role of LPA and LPA receptors for malignant pleural mesothelioma (MPM) has b...

Journal: :The Journal of biological chemistry 2008
Tânia Cristina Sampaio Spohr Ji Woong Choi Shannon E Gardell Deron R Herr Stevens Kastrup Rehen Flávia Carvalho Alcantara Gomes Jerold Chun

Lysophosphatidic acid (LPA) is a simple phospholipid derived from cell membranes that has extracellular signaling properties mediated by at least five G protein-coupled receptors referred to as LPA(1)-LPA(5). In the nervous system, receptor-mediated LPA signaling has been demonstrated to influence a range of cellular processes; however, an unaddressed aspect of LPA signaling is its potential to...

2011
Toshifumi Tsujiuchi Kyoko Okabe Nobuyuki Fukushima

Lysophosphatidic acid (LPA) is a bioactive mediator and induces several biological effects, including cell proliferation, migration, morphogenesis and differentiation. LPA interacts with at least six G protein-coupled receptors (GPCRs), including LPA receptor-1 (LPA(1)), LPA(2), LPA(3), LPA(4), LPA(5) and LPA(6). These receptors show different biological functions through the binding of LPA, de...

Journal: :Journal of cell science 2005
Nikhil M Urs Kymry T Jones Paul D Salo Jamie E Severin Joann Trejo Harish Radhakrishna

Lysophosphatidic acid (LPA) stimulates heterotrimeric G protein signaling by activating three closely related receptors, termed LPA(1), LPA(2) and LPA(3). Here we show that in addition to promoting LPA(1) signaling, membrane cholesterol is essential for the association of LPA(1) with beta-arrestin, which leads to signal attenuation and clathrin-dependent endocytosis of LPA(1). Reduction of clat...

2014
Marion David Debashish Sahay Florence Mege Françoise Descotes Raphaël Leblanc Johnny Ribeiro Philippe Clézardin Olivier Peyruchaud

Lysophosphatidic acid (LPA) is a natural bioactive lipid with growth factor-like functions due to activation of a series of six G protein-coupled receptors (LPA₁₋₆). LPA receptor type 1 (LPA₁) signaling influences the pathophysiology of many diseases including cancer, obesity, rheumatoid arthritis, as well as lung, liver and kidney fibrosis. Therefore, LPA₁ is an attractive therapeutic target. ...

Journal: :Journal of leukocyte biology 2007
Liana C Chan Wendy Peters Yan Xu Jerold Chun Robert V Farese Sylvaine Cases

Increasing evidence supports roles for lipids in the biology of immune cells. In particular, bioactive lipids such as sphingosine-1-phosphate (S1P) bind to cognate G protein-coupled receptors (GPCRs) and modulate leukocyte trafficking and homeostasis. Lysophosphatidic acid (LPA) represents a family of bioactive lipids, which differ in the length and degree of saturation of the fatty acyl chain....

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2015
Makoto Kurano Akiko Suzuki Asuka Inoue Yasunori Tokuhara Kuniyuki Kano Hirotaka Matsumoto Koji Igarashi Ryunosuke Ohkawa Kazuhiro Nakamura Tomotaka Dohi Katsumi Miyauchi Hiroyuki Daida Kazuhisa Tsukamoto Hitoshi Ikeda Junken Aoki Yutaka Yatomi

OBJECTIVE Lysophosphatidic acids (LPA) have important roles in the field of vascular biology and are derived mainly from lysophosphatidylcholine via autotaxin. However, in our previous study, only the plasma LPA levels, and not the serum autotaxin levels, increased in patients with acute coronary syndrome (ACS). The aim of this study was to elucidate the pathway by which LPA is increased in pat...

Journal: :Molecular and cellular biology 2002
James J A Contos Isao Ishii Nobuyuki Fukushima Marcy A Kingsbury Xiaoqin Ye Shuji Kawamura Joan Heller Brown Jerold Chun

Lysophosphatidic acid (LPA), a bioactive lipid produced by several cell types including postmitotic neurons and activated platelets, is thought to be involved in various biological processes, including brain development. Three cognate G protein-coupled receptors encoded by lpa(1)/lp(A1)/Edg-2/Gpcr26, lpa(2)/lp(A2)/Edg-4, and lpa(3)/lp(A3)/Edg-7 mediate the cellular effects of LPA. We have previ...

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