background: the exposure of cell lines to low-dose irradiation leads to changes at molecular level, which may induce adaptive response. we examined radio-adaptive doses effect on human colorectal adenocarcinoma cell line (ht29) and human fetal fibroblasts (mrc5) cell line followed by hyper and hypo fractionation regimes, with main purpose to decrease cell viability in ht29, and at the same time...

background: study of vascular and its secretory profile changes is an important issue in pathogenesis of radiation myelopathy. this paper reports the prostacyclin concentration changes after low-moderate doses of x-irradiation within a short period of time. materials and methods: cervical cords of wistar rats were irradiated to doses of 0.5, 1, 2, 4 and 6 gy x-rays. after 24 hours, 2 and 13 wee...

the frequency of chromosomal aberrations was studied in the peripheral blood lymphocytes of 65 radiology technologists crt) working at hospitals chronically exposed to x-rays. although film dosimetry did not show the maximal annual permitted dose in any of the examined subjects, cytogenetic analysis detected fairly high levels of chromosomal aberrations in r t compared to unexposed controls. th...

objective(s): although low-dose radiotherapy (rt) that involves low collateral damage is more suitable for hepatocellular carcinoma (hcc) than traditional high-dose rt, but to achieve satisfactory therapeutic effect with low-dose rt, it is necessary to sensitize hcc cells to irradiation. this study was aimed to determine whether radiosensitivity of hcc cells can be enhanced using mir-26b by tar...

Objective(s): Although low-dose radiotherapy (RT) that involves low collateral damage is more suitable for hepatocellular carcinoma (HCC) than traditional high-dose RT, but to achieve satisfactory therapeutic effect with low-dose RT, it is necessary to sensitize HCC cells to irradiation. This study was aimed to determine whether radiosensitivity of HCC cells can be enhanced using miR-26b by tar...

in order to improve the performance of a newly developed radiochromic film, gic-79, somedosimetric characteristics of this film have been studied based on relevant standard practice. the presentstudy describes some parameters that may affect the dosimeter response before, during, and after irradiation. the effect of absorbed dose rate on dosimeter response was determined by irradiating dosimete...

apoptosis, a physiologic mechanism to eliminate unwanted cells, is also induced by ionizing irradiation, through production of free radicals. it has been demonstrated that antioxidants such as vitamin e are able to protect cells from damage caused by free radicals. taken together we found it reasonable to make an attempt to evaluate the protective effect of vitamin e against apoptosis. the irra...