objective(s): the purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (ba) enhancement of potent sulfonamide- type loop diuretic- furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an adjunct in acute pulmonary edema. the comparatively poor and inconstant b...

      A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing th...

a major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. if the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. although some approaches are available for enhancing the diss...

in the present study, sodium alginate microparticle for oral delivery of furosemide was designed whether the encapsulation into microparticles might improve the oral absorption of this potent loop diuretic. we described preparation of microspheres based on ionotropic gelation method and characterized its physicochemical properties. to acquire an optimum formulation, a generalized regression neu...

Stealth liposomal doxorubicin (Doxil ® /Caelyx ®) passively targets to tumors through the enhanced permeability and retention (EPR) effect, which is a result of enhanced vascular permeability of tumor blood vessels. The endothelial lining of the diseased site contains gaps that can range from 380-780 nm which are large enough for the extravasation of liposomes (~100 nm). Once the liposomes are ...

Objective(s): The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an adjunct in acute pulmonary edema. The comparatively poor and inconstant B...

PURPOSE Pharmacokinetic studies on liposomal drugs have previously measured total drug levels in tumors, which include non-bioavailable drug. However, drugs must be released from liposomes to have activity. We have developed a method for measuring levels of bioavailable (released) doxorubicin in vivo in tumors that will allow therapeutic activity to be correlated with bioavailable drug levels. ...

One of the biggest challenges faced by pharmaceutical scientists is poor solubility and bioavailability of new chemical entities (NCEs). According to BCS classification; approximately 25% of all compounds are classified as highly soluble and permeable. Nearly 40% of the new chemical entities currently being discovered are lipophilic so poorly water soluble drugs. BCS Class II and Class IV have ...

Objective: The present investigation aims to formulate the ideal drug formulation using different surfactants and optimize amlodipine-loaded polymeric nanoparticles. Methods: work was drug-loaded nanoparticles enhance dissolution rate of a poorly water-soluble drug, amlodipine besylate, anti-solvent precipitation method. Characterisation studies include particle size (nm), Zeta potential (mV), ...

Given there is an optimal lipophilicity range for orally bioavailable drugs, structural modifications applied in the drug development process are not only focused on optimizing bioactivity but also...