lonophore-based ion-selective optical nanosensors have been explored for a number of years. Voltage sensitive dyes (VSDs) have been introduced into this type of sensors only very recently, forming a new class of analytical tools. Here, K(+)-sensitive nanospheres incorporating a lipophilic VSD were successfully fabricated and characterized. The nanosensors were readily delivered into the social ...

in this work, a novel zr02+ pvc-based membrane sensor based on 4,7,13,16,21,24-hexa oxa-1,10- diazabicyclo[8,8,8]- hexa cosane (hodbhc) as a new ionophore is presented. the sensor displays a linear dynamic rangebetween 1.0x 10-1 and 1.0x10 6 m, with a near nernstian slope of 29.9 ± 0.4 mv per decade in an acidic solution(ph=1). the limit of detection is 8.0 x 1 0 7 m. the electrodes possess adv...

.......................................................................................................... xi 1. ENDOTHELIUM-DEPENDENT VASODILATION: A REViEW ..................................... 1 What is the Nature of the Cholinergic, Endothelium-Dependent Response? 1 Endothelium-Derived Relaxing Factor ................................................. 2 Influence of Contractile Agent and Ton...

Four neurotoxins that activate the action potential Na+ ionophore of electrically excitable neuroblastoma cells interact with two distinct classes of sites, one specific for the alkaloids veratridine, batrachotoxin, and aconitine, and the second specific for scorpion toxin. Positive heterotropic cooperativity is observed between toxins bound at these two classes of sites. Tetrodotoxin is a nonc...

Pial arterioles on the surface of the mouse brain were observed in vivo under a chamber with a glass window. When placed under the window, calcium ionophore, acetylcholine, and previously acidified sodium nitrite each dilated the arterioles. If the cyclooxygenase inhibitors indomethacin or acetylsalicylic acid were first placed in the chamber, subsequent dilation of the arterioles by calcium io...