نتایج جستجو برای: loh
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مقدمه: سرطان کلورکتال یکی از شایعترین سرطان ها در سرتاسر جهان است. هفتاد و پنج درصد سرطان های کلورکتال تک گیر بوده و فاقد سابقه ی فامیلی می باشند. سه مسیر اصلی سرطان زایی در این سرطان ناپایداری کروموزومی، ناپایداری ریزماهواره ای و مسیر متیلاتور می باشند. مسیر ناپایداری کروموزومی در 85-80% سرطان های کلورکتال نقش دارد. در این مسیر، برخی از ژن های سرکوبگر تومور دچار تغییراتی می شوند. ژن apc از جمل...
Alkaloids of the aerial parts of chelidonium were extracted in the salt form, and their aqueous solutions were prepared in different concentrations. Rat hepatocytes were obtained by liver perfusion. The alkaloidal solutions were added to suspensions of hepatocytes in petri dishes and the mixtures were incubated. Two types of controls have been used in one type. no alkaloidal extract was ad...
Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. Our aim in this study was to illustrate microsatellite DNA alteration in esophageal cancer. Materials and Methods: DNA was extracted from formalin fixed paraffin embedde...
alkaloids of the aerial parts of chelidonium were extracted in the salt form, and their aqueous solutions were prepared in different concentrations. rat hepatocytes were obtained by liver perfusion. the alkaloidal solutions were added to suspensions of hepatocytes in petri dishes and the mixtures were incubated. two types of controls have been used in one type. no alkaloidal extract was added t...
objective(s): variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. our aim in this study was to illustrate microsatellite dna alteration in esophageal cancer. materials and methods: dna was extracted from formalin fixed paraffin embedde...
Loss of heterozygosity (LOH) occurs in a variety of diploid organisms after chemical mutagenesis and was observed in the vegetable pathogen Phytophthora capsici after N-ethyl-nitrosourea (ENU) mutagenesis at three loci during reverse genetic screening. Our objectives were to determine (i) the frequency of LOH among mutants, (ii) the directionality of the LOH events and (iii) the length of the g...
PURPOSE High-grade serous cancer (HGSC) is the most common cancer of the ovary and is characterized by chromosomal instability. Defects in homologous recombination repair (HRR) are associated with genomic instability in HGSC, and are exploited by therapy targeting DNA repair. Defective HRR causes uniparental deletions and loss of heterozygosity (LOH). Our purpose is to profile LOH in HGSC and c...
BACKGROUND AND AIMS 17p (TP53) loss of heterozygosity (LOH) has been reported to be predictive of progression from Barrett's esophagus to esophageal adenocarcinoma, but the mechanism by which TP53 LOH develops is unknown. It could be (a) DNA deletion, (b) LOH without copy number change, or (c) tetraploidy followed by genetic loss. If an alternative biomarker assay, such as fluorescence in situ ...
The increased chemosensitivity of oligodendroglial tumors has been associated with loss of heterozygosity (LOH) on chromosomes 1p and 19q. Other clinical and molecular factors have also been identified as being prognostic and predictive for treatment outcome. Seventy-seven patients with anaplastic oligodendroglioma (AO) or anaplastic oligoastrocytoma (AOA), treated in Beijing Tiantan Hospital f...
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