background the incidence of transient neurologic symptoms (tns) after spinal anesthesia with lidocaine is reported as high as 40%. objectives this prospective clinical trial was designed to determine the incidence of tns in patients who underwent spinal anesthesia with two different needles, in two different surgical positions. patients and methods the present randomized clinical trial was cond...

pain is a challenging health dilemma and has gained a great focus in clinico-pathological conditions correlated with post-operative, neuropathic and cancer pain. while perioperative administration of analgesics to mitigate the postoperative pain has been well established in the literature (termed preventive analgesia), preemptive analgesia or effects of any drug (such as anesthetics) prior to o...

it has been sugeested since long that peripheral nerves possess opiod receptors and this has tempted clinicans in adding narcotics to local anesthetics to prolong the analgesic effects of these solutions. in this regard, we studied 45 patients undergoing surgical procedures on upper extremities. the patients scheduled for surgery were divided in to three groups, each comprising of 15 patients a...

The primary mode of action of local anesthetics is through sodium channel and axonal conduction blockade. Local anesthetics have also extensive effects on pre-synaptic calcium channels that must function to stimulate the release of neurotransmitters. Thus, interference with calcium channel conductance may enhance spinal anesthesia with local anesthetics. The present study was designed to invest...

The primary mode of action of local anesthetics is through sodium channel and axonal conduction blockade. Local anesthetics have also extensive effects on pre-synaptic calcium channels that must function to stimulate the release of neurotransmitters. Thus, interference with calcium channel conductance may enhance spinal anesthesia with local anesthetics. The present study was designed to invest...

The first clinical uses of a local anesthetic agent occurred in 1884, when cocaine was employed as a topical agent for eye surgery and to produce a nerve block. These events inaugurated a new era, that of regional anesthesia. New applications were developed, including spinal, epidural, and caudal anesthesia. The search for a better local anesthetic led to chemical synthesis of a number of other...

the purpose of the present article is to carry out a review of the literature on two local anesthetic agents, which are the most commonly used drugs in dental procedures. it would provide a clear concept about the local anesthetics, their dosages and exact usage in dental surgeries.

toxic reactions to local anesthetics may occur due to over dose, accidental intravenous injections or rapid systemic uptake of the drugs. but there have been few reports on toxicity due to displacement of epidural catheters after an initial correct insertion and performance of a test dose.  here we present a case of local anesthetics toxicity due to possible displacement of the epidural cathete...