despite the fact that hepatic involvement is frequently seen in systemic primary amyloidosis, major hepatic symptoms as primary manifestation and severe impaired liver function are rare. herein, we report a 38-year-old woman with primary hepatic amyloidosis, and severe  portal hypertension . the patient had ascites and markedly elevated alkaline phosphatase level at presentation. she had a rapi...

The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to amyloidosis. Our patient had the primal symptoms of hyperbili...

Hyperimmunization of horses with specific antigens to harvest antisera is associated with high incidence of liver amyloidosis. The histopathologic examination is the gold standard method for diagnosis of the hepatic amyloidosis. The aim of the present study was to determine whether the clinical manifestations and serum values of appropriate chemical constituents due to liver injury, provide the...

systemic amyloidosis and testicular interstitial tumor are rare conditions in birds and this is the first report in iran. a male zebra finch was presented because of white diarrhea, anorexia, loss of weight and lethargy. at necropsy, the small intestine was edematous and congested. the spleen appeared pale. the liver was large, firm and brown. one testis was cystic and neoplastic and the remain...

 Hepatic involvement in AL amyloidosis may present as acute liver failure. Historically, liver transplantation in these cases has achieved poor outcomes due to progress of amyloidosis and non-hepatic organ damage. In the era of bortezomib treatment, the prognosis of AL amyloidosis has been markedly improved and may also result in better post-transplant outcomes. We present a case of isolated ac...

Systemic amyloidosis and testicular interstitial tumor are rare conditions in birds and this is the first report in Iran. A male zebra finch was presented because of white diarrhea, anorexia, loss of weight and lethargy. At necropsy, the small intestine was edematous and congested. The spleen appeared pale. The liver was large, firm and brown. One testis was cystic and neoplastic and the remain...

We read with interest the pictorial essay by Özcan et al. (1) entitled “Imaging for abdominal involvement in amyloidosis” in the recent issue of Diagnostic and Interventional Radiology. In this article, the authors provide both textual and visual portrayals of abdominal amyloidosis, which is difficult to diagnose because of nonspecific imaging findings and frequent subclinical presentation. Bot...

Introduction Patients suffering from amyloidosis frequently have liver involvement. Although some of the stigmata of chronic diffuse liver disease may be seen and some liver function tests may be abnormal, particularly the bromsulphthalein excretion and alkaline phosphatase, the presence of hepatic involvement in amyloidosis is usually of little clinical significance (Brandt, Cathcart and Cohen...

Hepatic involvement in primary amyloidosis is an infrequent challenge to the hepatologist. Although usually asymptomatic, amyloidosis may have unusual manifestations. Liver biopsy is an important diagnostic tool for this condition. Herein, we report three cases of portal hypertension related to primary hepatic amyloidosis, one of them in the form of acute liver failure.

Amyloidosis is a rare disorder with a wide spectrum of presentations and anomalies. It is subdivided into 2 broad categories based on protein deposition; primary and secondary amyloidosis. It can present as a single-organ involvement or as a diffuse infiltrative multi-organ process. Isolated hepatic amyloidosis presentation is a rare phenomenon that develops due to insoluble amyloid deposition ...