introduction: lithium salts are known as effective psychotropic medicine for treatment bipolar disorder and may be used to treat alcoholism, schizoaffective disorders, and cluster headaches. the antioxidant activity and immunomodulatory effects of prospective lithium compounds have been investigated in this work. materials and methods: the antioxidant properties were studied by the voltammetry ...

We have shown that lithium treatment improves motor coordination in a spinocerebellar ataxia type 1 (SCA1) disease mouse model (Sca1(154Q/+)). To learn more about disease pathogenesis and molecular contributions to the neuroprotective effects of lithium, we investigated metabolomic profiles of cerebellar tissue and plasma from SCA1-model treated and untreated mice. Metabolomic analyses of wild-...

Introduction: Lithium salts are known as effective psychotropic medicine for treatment bipolar disorder and may be used to treat alcoholism, schizoaffective disorders, and cluster headaches. The antioxidant activity and immunomodulatory effects of prospective lithium compounds have been investigated in this work. Materials and Methods: The antioxidant properties were studied by the voltammetry...

Lithium salts are used in medicine as normotimics. An important aspect of the action any medicine, incl. lithium is their effect on human microbiota (microbiome). This work presents results a comparative chemomicrobiome analysis organic salts: ascorbate, comenate, nicotinate, oxybutyrate, aspartate and orotate, carried out using modern technologies for “big data”. For each studied salts, estima...

In this work, we study the neuroprotective properties of lithium ascorbate in vivo and vitro stress models. Neurocytological behavioral studies were carried out on models both a culture nerve cells experimental animals. The studied drug showed significant effect neuronal cultures exposed to glutamate toxicity an adaptogenic rats. results suggest that possess high potential .

The paper describes modern ways for selection of anti-radical substances. Molding of such components with a carbon-based material decreases the rate of its oxidative destruction. Addition of such a component to a carbon-based material decreases the rate of its oxidative destruction. The purpose of this study is to determine the antioxidant activity of ascorbates metals (Ca, Mg, Li, Co, Fe), use...

It is well known that a complex of nervous and hormonal signals during stress stimulates adrenal glands to secrete adrenaline, norepinephrine cortisol. Much less attention has been paid the roles intermediate signaling proteins mediating effects “stress hormones”, neurotransmitters, other molecules. This paper presents results systematization studies glycogen synthase kinases GSK-3α GSK-3β, who...

Introduction. Radioresistance of cancer cells is a serious problem in radiation therapy tumor diseases. Radiosensitizers make malignant more sensitive to and increase the effectiveness therapy; however, their widespread clinical use limited by significant side effects. The development study new radiosensitizers seems be an urgent task modern pharmacology. Aim. purpose this work was lithium asco...

background: lithium has been the treatment of choice for bipolar disorder (bd) for many years. although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. objective: the aim was to investigate the possible involvement of nitric oxide (no) in modulatory effect of lithium on penile erection (pe). we fur...