The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was investigated. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of aging on the dissolution behaviour of indomethacin liquisolid compacts was investigated. To evaluate any interaction be...

The aim of present study was to improve the solubility of pioglitazone HCl a practically insoluble antidiabetic drug by using liquisolid technique. The in vitro release pattern of liquisolid tablets and directly compressed tablets were studied using USP-II apparatus. Different Liquisolid tablets were prepared using a mathematical model to calculate the required quantities of powder and liquid i...

Liquisolid system is a novel concept of dosage formulation for water insoluble drugs and lipophilic drugs via oral route. Formulation concept of liquisolid technology involves water insoluble drugs dissolved in suitable non-volatile liquid vehicles, and converted in to compact by blending with selective powder excipients. Liquisolid compacts are compressible powdered forms of liquid medications...

The main objective of this study is to improve the dissolution and there by availability of Irbesartan a practically insoluble drug by liquisolid Compact technique. The liquisolid tablets of Irbesartan were prepared by using various ratio of carrier (Avicel PH 102) to coating (Cab-O-Sil M5) material using PEG 400 as non volatile solvent. The prepared liquisolid tablets were evaluated for hardne...

This investigation was aimed to improve the dissolution rate of the poorly soluble drug lovastatin, by formulating it as a liquisolid compact. Different liquisolid compacts were prepared using mathematical formulae to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH 200, Cab-O-Sil, sodium starch glycolate and...

Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formulation into liquisolid tablets and then to investigate in vitro performance of prepared liquisolid systems. By use of this technique, liquid medications such as solutions or sus...

BACKGROUND A liquisolid technique has been reported to be a new approach to improve the release of poorly water-soluble drugs for oral administration. However, an apparent limitation of this technique is the formulation of a high dose because a large amount of liquid vehicle is needed, which finally results in a low-dose liquisolid formulation. Silica as an absorbent has been used extensively i...

The aim of our study was to improve the availability of Rofecoxib a practically insoluble non-steroidal anti-inflammatory drug, as a model drug by using liquisolid technique. The effect of powder substrate composition on the flowability and compressibility of liquisolid compacts were evaluated. Specifically, several liquisolid formulations, containing 25-mg Rofecoxib, which containing different...

The purpose of the present research was to study the effects of Ceolus KG-802 on the dissolution behavior of fenofibrate liquisolid tablets. The fenofibrate liquisolid tablets were formulated using the mathematical model described by Spireas et al. In the present research, Ceolus KG-802, a different form of microcrystalline cellulose (PH 102 grade), was used as a carrier material. The developed...

A liquisolid system has the ability to improve the dissolution properties of poorly water soluble drugs. Liquisolid compacts are flowing and compactable powdered forms of liquid medications. The aim of this study was to enhance the in vitro dissolution properties of the practically water insoluble loop diuretic furosemide, by utilising liquisolid technique. Several liquisolid tablets were prepa...