Introduction: Several reports show a relationship between health equity, and health status and longevity of individuals. In this study, effects of food deprivation, inequality and social instability were investigated on the formation of lipofuscin pigment in Balb/C mice by histopathological and biochemical methods. Methods: Thirty-six male mice were divided into 6 groups, then different kind...

this study investigated the cytochemical responses in hediste diversicolor exposed to the environmental concentrations of cadmium (1µm cd), copper (1µm cu) and to their equimolar mixture for 48h. lysosomal membrane stability (lms), neutral lipids (nl) level, lipofuscin (lf) content and ca2+-atpase activity were determined as early subcellular biomarkers of toxicity. the biomarker battery pointe...

Retinal lipofuscin which accumulates with age in the retinal pigment epithelium (RPE) is subjected to daily exposures high fluxes of visible light and exhibits potent photosensitising properties; however, molecules responsible for its photoreactivity remain unknown. Here, we demonstrate that autooxidation docosahexaenoate (DHE) leads formation products absorbing, addition UVB UVA light, also li...

The ageing process is accompanied by numerous changes in the brain of dogs, such as accumulation amyloid, fibrosis blood vessel walls and meninges, lipofuscin, presence polyglucosan bodies (PGBs), satellitosis neuronophagia. In this study, lipofuscin PGBs various parts dogs different sexes ages was examined. For purpose, samples were stained using haematoxylin eosin, modified Ziehl Neelsen Peri...

PURPOSE Lipofuscin accumulates in human retinal pigment epithelium (RPE) cells with age and may be the main factor responsible for the increasing susceptibility of RPE to photo-oxidation with age. As the composition, absorption, and fluorescence of lipofuscin undergo age-related changes, the purpose of this study was to determine whether photoreactivity of lipofuscin granules also changes with ...

BACKGROUND/AIM Considering available literature lipofuscin is a classical age pigment of postmitotic cells, and a consistently recognized phenomenon in humans and animals. Lipofuscin accumulation is characteristic for nerve cells that are postmitotic. This research was focused on lipofuscin accumulation in ganglionic cells (GC) (postganglionic sympathetic cell bodies) of superior cervical gangl...

A brief overview is here provided on lipofuscin and lipofuscin-like substances, with particular reference to their biological significance as well as to their cellular origin and pathophysiological role. Special emphasis is also placed on the mutual relationships between lipofuscin and lipofuscin-like lipopigments on one side, and cell autofluorescence on the other.

Twenty-four human retinas were structurally examined in order to study the degradative pathway in inner segment turnover. Lipofuscin granules were found in myoids of photoreceptor inner segments. Cone lipofuscin granules exhibited autofluorescence, in ultraviolet light. Both the cone lipofuscin granules (-1.6 micron) and the rod ones (-0.6 micron) were membrane-limited inclusions comprising dif...