linguatula serrata, well known as tongue worm; is an aberrant cosmopolitan parasite, which inhabits the canine respiratory system (final host). the discharged eggs infect many plant feeder animals including human causing visceral and nasopharyngeal linguatulosis which is known as “marrara syndrome”. in current study, the prevalence of infection with l. serrata nymphs in mesenteric lymph nodes (...

linguatula serrata is one of the important zoonotic parasites. carnivores serve as definitive host. the larvae existed in mesenteric lymph nodes (mlns), liver, lungs, etc of intermediate herbivores. the definitive host becomes infected by ingesting viscera containing the infective nymphal stage. humans may be infected with linguatula either by ingestion of nymphs resulting in a condition called...

Linguatula serrata, well known as tongue worm; is an aberrant cosmopolitan parasite, which inhabits the canine respiratory system (final host). The discharged eggs infect many plant feeder animals including human causing visceral and nasopharyngeal linguatulosis which is known as “Marrara syndrome”. In current study, the prevalence of infection with L. serrata nymphs in mesenteric lymph nodes (...

linguatula serrata, is a cosmopolitan zoonotic parasite. adult of l. serrrata parasitize the nasopharynx of canids. con­suming raw glandular material of infected intermediate hosts (camel, sheep, cattle, goat, etc.) can infect human. in iran, two-humped camel is merely found in cold regions (ardabil and east azarbijan provinces) and is in danger of extinc­tion. a seven-year-old two-humped male ...

Serrate-like genes encode transmembrane ligands to Notch receptors and control cell fate decisions during development. In this report, we analyse the regulation of the mouse Serrate-1 gene during embryogenesis. The Serrate-1 gene is expressed from embryonic day 7.5 (E7.5) and expression is often observed at sites of epithelial-mesenchymal interactions, including the developing tooth, where Serr...

Linguatula serrata is one of the important zoonotic parasites. Carnivores serve as definitive host. The larvae existed in mesenteric lymph nodes (MLNs), liver, lungs, etc of intermediate herbivores. The definitive host becomes infected by ingesting viscera containing the infective nymphal stage. Humans may be infected with Linguatula either by ingestion of nymphs resulting in a condition called...

In the developing imaginal wing disc of Drosophila, cells at the dorsoventral boundary require localized Notch activity for specification of the wing margin. The Notch ligands Serrate and Delta are required on opposite sides of the presumptive wing margin and, even though activated forms of Notch generate responses on both sides of the dorsoventral boundary, each ligand generates a compartment-...

Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was thought to participate in this process. We now show that macrochaete lateral inhibition involves both Delta and Serrate. In this context, Serrate interacts with Neuralized, a...

The Notch ligands, Delta/Serrate/Lag-2 (DSL) proteins, mediate the Notch signaling pathway in a numerous developmental processes in multicellular organisms. Although the ligands induce the activation of the Notch receptor, the intracellular domain-deleted forms of the ligands cause dominant-negative phenotypes, implying that the intracellular domain is necessary for the Notch signal transductio...

Cell-to-cell communication via the Notch pathway is mediated between the membrane-bound Notch receptor and either of its canonical membrane-bound ligands Delta or Serrate. Notch ligands mediate receptor transactivation between cells and also mediate receptor cis-inhibition when Notch and ligand are co-expressed on the same cell. We demonstrate in Drosophila that removal of any of the EGF-like r...