نتایج جستجو برای: lingo

تعداد نتایج: 806  

Journal: :Investigative ophthalmology & visual science 2008
Qing-Ling Fu Bing Hu Wutian Wu R Blake Pepinsky Sha Mi Kwok-Fai So

PURPOSE LINGO-1 is a functional member of the Nogo66 receptor (NgR1)/p75 and NgR1/TROY signaling complexes that prevent axonal regeneration through RhoA in the central nervous system. LINGO-1 also promotes cell death after neuronal injury and spinal cord injury. The authors sought to examine whether blocking LINGO-1 function with LINGO-1 antagonists promotes retinal ganglion cell (RGC) survival...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Haruhisa Inoue Ling Lin Xinhua Lee Zhaohui Shao Shannon Mendes Pamela Snodgrass-Belt Harry Sweigard Tom Engber Blake Pepinsky Lichuan Yang M Flint Beal Sha Mi Ole Isacson

The nervous system-specific leucine-rich repeat Ig-containing protein LINGO-1 is associated with the Nogo-66 receptor complex and is endowed with a canonical EGF receptor (EGFR)-like tyrosine phosphorylation site. Our studies indicate that LINGO-1 expression is elevated in the substantia nigra of Parkinson's disease (PD) patients compared with age-matched controls and in animal models of PD aft...

Journal: :The Journal of pharmacology and experimental therapeutics 2014
R Blake Pepinsky Joseph W Arndt Chao Quan Yan Gao Omar Quintero-Monzon Xinhua Lee Sha Mi

Multiple sclerosis (MS) is an autoimmune-inflammatory disease of the central nervous system (CNS) with prominent demyelination and axonal injury. While most MS therapies target the immunologic response, there is a large unmet need for treatments that can promote CNS repair. LINGO-1 (leucine-rich repeat and Ig-containing Nogo receptor interacting protein-1) is a membrane protein selectively expr...

2012
Camilla Lööv Maria Fernqvist Adrian Walmsley Niklas Marklund Anna Erlandsson

Identifying external factors that can be used to control neural stem cells division and their differentiation to neurons, astrocytes and oligodendrocytes is of high scientific and clinical interest. Here we show that the Nogo-66 receptor interacting protein LINGO-1 is a potent regulator of neural stem cell maturation to neurons. LINGO-1 is expressed by cortical neural stem cells from E14 mouse ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
Zhaohui Shao Xinhua Lee Guanrong Huang Guoqing Sheng Christopher E Henderson Daniel Louvard Jiho Sohn Blake Pepinsky Sha Mi

Differentiation and maturation of oligodendrocyte progenitor cells (OPCs) involve the assembly and disassembly of actin microfilaments. However, how actin dynamics are regulated during this process remains poorly understood. Leucine-rich repeat and Ig-like domain-containing Nogo receptor interacting protein 1 (LINGO-1) is a negative regulator of OPC differentiation. We discovered that anti-LING...

Journal: :Nature 1990

Journal: :Laboratory Medicine 2009

2016
Melissa M Gresle Yaou Liu Trevor J Kilpatrick Dennis Kemper Qi-Zhu Wu Bing Hu Qing-Ling Fu Kwok-Fai So Guoqing Sheng Guanrong Huang Blake Pepinsky Helmut Butzkueven Sha Mi

BACKGROUND Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron and oligodendrocyte survival, axon regeneration, and (re)myelination. The therapeutic effects of ant...

2014
Ming-Tung Hong Yung-Jen Hsu

Lingo is an emerging language on the Internet. Providing a standardized definition remains difficult due to continuous changes made to its nature. We proposed Tranzzl!n9o, a crossword puzzle game for engaging crowds to translate Internet lingo. Players provide explanations for lingo in parallel and iteratively verify the explanations from other players. Crowd-sourced translations are very infor...

2015
Rian de Laat James S. Meabon Jesse C. Wiley Mark P. Hudson Thomas J. Montine Mark Bothwell

Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the plasma membrane. However, this pathogenic mode of processing AβPP may occur in competition with lysosomal degradation...

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