For decades, investigators have made numerous attempts to generate human pancreatic β cell lines that could be used to advance β cell biology, facilitate drug discovery, and provide a pathway to β cell replacement therapy for the treatment of diabetes. In this issue of the JCI, Ravassard and colleagues report that this has finally been achieved successfully with a multistep process that led to ...

Focus particles interact with the focused constituent in a sentence. The particle only presents a challenge to formalizing this relationship as while it commonly precedes the focused constituent, only can also follow it. A syntactic account of these constructions is presented that captures the unique properties of only’s distribution within the framework presented in Kayne (1998) and offers sup...