objective(s) using a cancer murine model of invasive aspergillosis (ia), we investigated the expression of tlr-2, dectin-1 and the level of cytokine production by cd4+ t helper cells in different groups of mice (with or without cancer), also, the effect of invasive aspergillosis on the immune response pattern of cancer mice. materials and methods patterns of susceptibility and resistance to inf...

background: stroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. toll-like receptors (tlrs) are important molecules for detection of both pathogen invasion and tissue damage. in this regard, the purpose of this study was to assess the expression level of tlr2 on monocytes in patients with ischemic stroke and to evaluate th...

conclusions tlr8 rs3764880 and tlr9 rs148805533 polymorphisms may not be risk factors for susceptibility to tuberculosis in a sample of iranian population. larger studies are required to validate our findings. results the allelic and genotypic frequencies of the tlr8 rs3764880 did not differ significantly between ptb and the controls. no significant difference was found between the groups regar...

conclusions this study suggests that decrease in levels of tlr3 and tlr7 expression is a mechanism that may enable hcv to evade the host innate immune response. results in both groups, we had 13 males and 12 females with a mean age of 48.7 ± 16. tlr3 (6.23 ± 0.91 vs. 3.89 ± 0.85, p < 0.001) and tlr7 (1.48 ± 0.82 vs-1.33 ± 1.18, p < 0.001) expressions were significantly lower in patients with ch...

introduction: the hippocampus (hip), the primary brain structure related to learning and memory, receives sparse but comprehensive dopamine innervations and contains dopamine d1/d2-like receptors. it is demonstrated that dopamine receptors in dentate gyrus (dg) region of hip have a remarkable function in spatial reward processing. much less is known about the involvement of hip and its d1/d2 do...

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there is no functional annotation for the majority of the several hundreds of receptor-like kinases in plants. a direct way of inferring the function of these proteins is to study the phenotype that results from loss of function mutants such as t-dna mutant lines. in this research a function (phenotype) to at2g37050 gene that encodes a receptor like kinase in arabidopsis t-dna line was assigned...

the hydrophobic proteins of plant plasma membrane still remain largely unknown.  for example in the arabidopsis genome, receptor-like kinases (rlks) are plasma membrane proteins, functioning as the primary receptors in the signaling of stress conditions, hormones and the presence of pathogens form a diverse family of over 610 genes. a limited number of these proteins have appeard in protein pro...

bacground: evidence from several lines of investigations suggests that toll-like receptor 4 (tlr4) is involved in atherosclerosis as a bridge between innate and acquired immunity. percutaneous coronary intervention (pci) can trigger inflammation through activation of human tlr4 (htlr4) on monocytes. hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of a...