pelizaeus­-merzbacher-like disease (pmld) is a hypomyelinating leukoencephalopathy disorder with a genetically heterogeneous pattern. mutations in the gja12/gjc2 gene cause one form of autosomal recessive pelizaeus­-merzbacher-like disease. here, we report a new mutation in a ­10-month-old girl with nystagmus, psychomotor delay, hypotonicity, head nodding and dysmyelination from healthy second ...

how to cite this article: karimzadeh p. pelizaeus-merzbacher- disease (pmd) and pelizaeus-merzbacher-like disease (pmld). iran j child neurol autumn 2014;8:4 (suppl.1):9-10.   pls see pdf.

introduction: behcet's disease is a chronic disease with multisystem involvement characterized clinically by oral and genital aphthae, cutaneous lesions and ophthalmologic, neurologic and gastrointestinal manifestation. nervous system involvement occurs in 5.3 – 30% of patients, mostly in brain stem and basal ganglia. the common manifestations are pyramidal signs, central nervous plegia, p...

prolonged cough occurs in a large proportion of the 2 million pilgrims who participate in the annual hajj in saudi arabia. there is no unique cause for pilgrims’ respiratory involvement, but several studies suggest a high incidence of influenza as a cause of the disease. to determine influenza vaccine efficacy against respiratory disease in pilgrims, we conducted two similar cohort studies on 5...

kawasaki disease (kd) is an acute febrile systemic vasculitis of childhood characterized by elevated levels of inflammatory mediators at the acute stage. high-dose intravenous immunoglobulin (ivig) is well accepted as a conventional therapy for kd. the aim of the present study was to determine the expression level of toll like receptors (tlrs) and their corresponding signaling mediators in pbmc...

introduction: dyspepsia, gastroesophageal reflux disease (gerd) and irritable bowel syndrome (ibs) are the most common gastrointestinal diseases. their prevalence is 18-30%, 25-30% and 10-15% in western communities and 8-14%, 3-7% and 3-5% in eastern countries, respectively. there is no adequate data about their prevalence in our country. the aim of this study is to determine the prevalence of ...

samples of leaf, twig and fruit from ‘mexican’ lime (citrus aurantifolia) and grapefruit (citrus paradisi) with symptoms of bacterial canker were collected from different provinces throughout iran during spring and summers of 2010 and 2011. yellow, gram-negative colonies were isolated from infected tissue samples. results of pathogenicity assays indicated that some isolates incited tissue hyper...

A 15-year-old boy presented with several months history of bilateral axillary lymph adenopathies which were ulcerated subsequently. He had received anti-tuberculosis therapy for more than six months based on suspicious diagnosis of scrofuloderma. Histopathologic examination confirmed the diagnosis of specific lesions of Hodgkin’s disease. These lesions were probably metastatic due to retrograde...

During the Coronavirus disease 2019 (COVID-19) pandemic, children are less affected than adults, and underlying conditions and older age are associated with severe disease. Following the SARS-CoV-2 pandemic, outbreaks of cases with Kawasaki-like disease and a few others with the multisystem inflammatory syndrome in children related to COVID-19 (MIS-C) have been reported. Here, we report a two-y...

Giant chorioangioma is a placental tumor associated with gestational complications such as preeclampsia, polyhydramnios and hemorrhage. In addition, this tumor might lead to the incidence of non-immune fetal hydrops, heart failure, anemia, thrombocytopenia, weight loss and death among neonates. In this case report, the clinical image of a term newborn (weighing 2800 g) with one-minute Apgar sco...