background: interaction between local anesthetic solution, lidocaine hydrochloride (with and without adrenaline), and root canal irrigants such as sodium hypochlorite (naocl), ethylene diamine tetra-acetic acid (edta), and chlorhexidine (chx) has not been studied earlier. hence, the purpose of this in vitro study was to evaluate the chemical interaction between 2% lidocaine hydrochloride (with ...