نتایج جستجو برای: lewy body disease

تعداد نتایج: 2087915  

Journal: :asia oceania journal of nuclear medicine and biology 0
yoshito kamiya graduate school of health sciences, kumamoto university, kuhonji 4-24-1, chuo-ku, kumamoto 862-0796, japan satoru ota graduate school of health sciences, kumamoto university shintaro okumiya graduate school of health sciences, kumamoto university kosuke yamashita fujifilm ri pharma co.,ltd. akihiro takaki faculty of life sciences, kumamoto university, shigeki ito department of medical imaging, faculty of life sciences, kumamoto university, kuhonji 4-24-1, kumamoto 862-0796, japan

objective(s): iodine-123 metaiodobenzylguanidine (123i-mibg) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in lewy body disease (lbd), including parkinson’s disease (pd) and dementia with lewy bodies (dlb). the heart-tomediastinum ratio (h/m) in pd and dlb is significantly lower than that in parkinson’s plus syndromes and alzheimer’s disease. although this ra...

Journal: :Journal of Neurology, Neurosurgery & Psychiatry 2004

Journal: :Proceedings of the Japan Academy, Series B 2014

CJ Heo

Human ?-synuclein is a 140 amino acid protein with little or no secondary structure. The ?-synuclein is expressed at high levels in the brain and enriched in neural synaptic terminals but its physiological function remains largely unknown. More recently, ?-synuclein has been shown to be one of the principal componets of Lewy bodies, neuronal inclusions that are found in diverse human neurodegen...

2003
Kanna K Gnanalingham Jane Byrne Andrew Thornton Mike A Sambrook Paul Bannister

Objective-Motor and cognitive function were compared in patients with Lewy body dementia, Parkinson's disease, or Alzheimer's disease, to identify features that may be clinically useful in differentiating Lewy body dementia from Alzheimer's disease and Parkinson's disease. Methods-A range of neuropsychological function and extrapyrimidal signs (EPS) was assessed in 16 patients with Lewy body de...

Journal: :Journal of neurology, neurosurgery, and psychiatry 1998
L A Hansen S E Daniel G K Wilcock S Love

OBJECTIVES Dementia in Alzheimer's disease correlates closely with loss of neocortical synapses. Similar synaptic loss has been shown in patients whose Alzheimer's disease is also associated with neocortical and brain stem Lewy bodies. The aim was to determine if dementia in Lewy body disease was associated with diminished concentrations of midfrontal cortex synaptophysin. METHODS An immunobi...

Journal: :Journal of neurology, neurosurgery, and psychiatry 1989
G Lennox J Lowe M Landon E J Byrne R J Mayer R B Godwin-Austen

Diffuse Lewy body disease is an important pathological substrate of the common syndrome of parkinsonian dementia. The new technique of anti-ubiquitin immunocytochemistry has been used in a correlative quantitative neuropathological study of fifteen cases of diffuse Lewy body disease, showing that the severity of dementia is related to cortical Lewy body density, whilst subcortical abnormalities...

Journal: :Journal of neurology, neurosurgery, and psychiatry 2004
D J Burn

C ortical Lewy body disease is a pathological observation rather than a distinct clinicopathological entity. Cortical Lewy bodies (CLB) are typically found in Parkinson’s disease and dementia with Lewy bodies (DLB), although they may also occur in other neurological disorders. Unlike their brain stem counterparts, CLB are less distinctive and are poorly visualised using conventional histochemic...

Journal: :Internal medicine 1995
Kenji Kosaka

Diffuse Lewy body disease (DLBD) has been studied from various viewpoints and, although clinical diagnostic criteria for DLBD have been proposed, diagnosis remains difficult. DLBD has been reported to be the second most common form of dementia in the aged, following Alzheimer-type dementia. It has, however, been clinically under-diagnosed. Therefore, the search for diagnostic markers for DLBD m...

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