Levobupivacaine is an enantiomer of racemic bupivacaine with a safe pharmacological profile. We present a review of levobupivacaine and its current clinical use in regional anaesthesia and pain management. The pharmacokinetic and pharmacodynamic profile of levobupivacaine is discussed and a qualitative review of studies involving levobupivacaine for regional anaesthesia is presented. Comparison...

Evidence suggests that levobupivacaine has similar pharmacodynamic properties to racemic bupivacaine. We sought to investigate whether this similarity extends to opioid sparing when levobupivacaine is used for epidural analgesia in laboring women by quantifying the effect of fentanyl on the minimum local analgesic concentration (MLAC) of levobupivacaine. One-hundred-six women requesting epidura...

Background: Fascia Iliaca Compartment Block (FICB) is commonly used in older patients to provide effective analgesia following hip fracture.  Objectives: However, only limited Pharmacokinetic (PK) data about levobupivacaine are available to help clinical practice and establish safe volumes and amounts of local anesthetics. Methods: Ten patients aged between 53 and 87 years, who underwent hemi...

BACKGROUND The goal of this in vitro study was to investigate the effects of lipid emulsion (LE) on local anesthetic levobupivacaine-induced responses in isolated rat aorta and to determine whether the effect of LE is related to the lipid solubility of local anesthetics. METHODS Isolated rat aortic rings were suspended for isometric tension recording. The effects of LE were determined during ...

BACKGROUND In an axillary brachial plexus block (ABPB), where relatively large doses of local anesthetics are administered, levobupivacaine is preferred due to a greater margin of safety. However, the efficacy of levobupivacaine in ABPB has not been studied much. We performed a prospective, double-blinded study to compare the clinical effect of 0.375% levobupivacaine with 0.5% levobupivacaine f...

INTRODUCTION Spinal anesthesia is a widely used technique of the modern practice of anesthesia. Spinal cord ischemia is a rare but catastrophic complication of spinal anesthesia which may be caused by a direct vasoconstrictive effect of the local anesthetic. Although the vasoconstrictive effects of levobupivacaine have been widely studied, the vasoconstrictive effects of this drug on the intrad...

OBJECTIVES We aimed to investigate whether the timing of administration, using a combination of incisional and intraperitoneal levobupivacaine (0.25%), has an effect on the postoperative pain after laparoscopic cholecystectomy in a prospective, randomized, and controlled study. METHODS Sixty six patients were allocated to one of the three groups. Group BS received levobupivacaine before troca...

conclusions the addition of s (+)-ketamine or clonidine to levobupivacaine 0.25% in caudal analgesia for hypospadias repair appears to be of no benefit. however, use of the additives in combination increased postoperative sedation. results the 87 patients included had a mean ± sd age of 21.4 ± 13.5 months and weight of 11.9 ± 2.4 kg. the median doses of levobupivacaine, s (+)-ketamine, and clon...

PURPOSE To evaluate the effects of levobupivacaine on neuromuscular transmission and neuromuscular blockade produced by pancuronium in vitro. METHODS Thirty rats were distributed into groups (n = 5) according to the drug used alone or in combination: Group I - levobupivacaine (5 µg.mL-1); Group II - pancuronium (2 µg.mL-1); Group III - pancuronium (2 µg.mL-1) + levobupivacaine (5µg.mL-1). The...

Background: Different additive drugs such as opioids, epinephrine, clonidine, and neostigmine have been used along with local anaesthetics to improve the duration and quality of analgesia. Few studies have demonstrated the increase of efficacy in various aspects after combining dexmedetomidine and ropivacaine and dexmedetomidine to caudal bupivacaine in pediatric major abdominal cancer surgerie...