abstract background: the family of cancer patients experience burden of care because of their caring role. therefore, appropriate and effective interventions are essential in order to decrease burden. the goal of the present research was to determine the effect of a family need–based program on the burden of care in caregivers of leukemia patients. materials and methods: in this clinical resear...

Background: Leukemia is one of the major causes of mortality and disability and the seventh most prevalent cancer worldwide. It has various effects on different aspects of physical, psychological, reproductive, social, and economic performance of human life. This study compared the quality of life of patients with different types of leukemia hospitalized in Ayatollah Khansari Hospital in Arak- ...

Midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. Herein, we describe a case of acute pre B cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. At the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. Our case sug...

results the tt virus infection was significantly found in 40 of 95 (42.1%) and 12 of 100 (12%) patients with leukemia and controls, respectively. the hbs-ag and hcv-ab were detected in 27 of 95 (28.4%) and 18 of 69 (26.1%) patients with leukemia but were not found in the controls. active cmv infection was also found in 11 of 69 (16%) patients and none of the controls. significant co-infection o...

Background and Aims: DNA methyltransferase3A (DNMT3A) is necessary for the adjustment of gene expression, and the mutations in the DNMT3A gene are reported in a variety of leukemia cases. DNMT3A mutations are during cancer progression and cause poor prognosis in many leukemias. Thus, this gene can be a target for new treatments. This study aimed to examine the distribution of DNMT3A mutations i...

background : we conducted the present study to investigate the frequency of prothrombin g20210a mutation among acute lymphoblastic leukemia patients and healthy individuals from western iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population. methods : the studied groups consisted of 92 children with acute lymphoblastic le...

Background: Several studies have examined the presence of DNA methylation of CpG islands in leukemia. Methylation of SOX17 and RUNX3 genes may play a role in leukemogenesis through silencing tumor suppressor genes. We investigated the methylation status of SOX17 and RUNX3 genes in patients with acute leukemia.    Methods: In this case-control study, peripheral blood samples from 100 AML and 10...

introduction: leukemia is a malignant disorder resulting from clonal proliferation of lymphoid or myeloid precursors with arrested maturation. it has been shown recently that telomers and telomerase activity are involved in the control of cell proliferation, regulation of cell senescence in the most somatic cells, and unlimited proliferation capacity of the malignant cells including leukemic ce...

conclusions the results of this review showed that the number of studies on the use of complementary medicine in leukemia patients is very limited (especially in iran), and it can be the subject of numerous studies in the future. results the overall results showed that few studies have been conducted on the use of exercise, massage therapy, music therapy, acupressure, and healing touch in patie...

patients with lymphoproliferative disorders have cellular immune deficiency and are susceptible to typical and atypical mycobacterial infections.hairy cell leukemia is a b-cell type lymphoproliferative disorder.2-cda is the choice of treatment for patients with hairy cell leukemia. it is a synthetic antineoplastic agent with immunosuppressive effects.we present development of pulmonary and meni...