We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.

in the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. among the ligands tested, diacetyl-bis(n4-methylthiosemicarbazones) (atsm) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde bis(n4-methyl)thiosemicarbazone (ptsm) was shown to possess low toxicity (7% let...

objective(s): this study aimed to determine the possible toxicity of cuo nanoparticles (nps) on oncorhynchus mykiss by evaluating hematological parameters.materials and methods: fish were sampled and treated in 4 aquariums containing the concentration ranges of 1, 5, 20 and 100 ppm of cuo nps. there was one control group (no cuo nps) and three replicates. the physicochemical properties of water...

the effects of chronic administration of lithium, on acute toxicity of carbamazepine (cbz) in mate albino mice was studied and the ld50 values were determined from dose-probit curves. the results showed that in lithium pretreated animals (animals consumed drinking water contraining 600 mg/l lithium carbonate for 10 days) the ld50 value (the doese corresponding to probit 5) of cbz decreased sign...

the effects of chronic administration of lithium, on acute toxicity of chlorpromazine (cpz) in male albino mice was studied and the ldso values were determined from dose-probit curves. tfie results showed that in lithium pretrealed animals (anmials consumed drinking water containing 600mg/l lithium chloride for 10 days) the ld50 value (the dose corresponding to probit 5) of cpz increased signif...

OBJECTIVE Suicide is a major public health concern. This study aimed to determine the predictors of repeated suicide attempts, focusing on whether lethality level of the suicidal method predicts the risk of subsequent suicide attempts. METHODS All consecutive individuals (N=2,070) with an episode of nonfatal self-harm registered in a surveillance database provided by the Department of Health ...

Mutations in Kirsten rat-sarcoma (KRAS) are well appreciated to be major drivers of human cancers through dysregulation of multiple growth and survival pathways. Similar to many other non-kinase oncogenes and tumor suppressors, efforts to directly target KRAS pharmaceutically have not yet materialized. As a result, there is broad interest in an alternative approach to develop therapies that ind...

egg-laying hens were immunized with the echis carinatus venom and the resulting antibodies were extracted from egg yolk by four different purification methods. the chicken egg yolk antibodies were purified by the water dilution method, polyethylene glycol (peg) and ammonium sulphate precipitation method, chloroform extraction and the lithium sulphate precipitation method. these methods were com...

in this study, a numerical model was developed to investigate the two-dimensional heat transfer in a homogenous finite cylinder to predict the local temperature and sterilizing value during caviar pasteurization. a fixed grid finite difference method was used in the solution of heat transfer equations according to crank-nicolson’s scheme. the model was validated by comparison of the experimenta...