The Leser-Trelat sign is the sudden appearance and rapid increase in size and number of seborrhoeic keratoses in association with cancer. Twenty cases of this unusual phenomenon have so far been reported in the world literature. More than half involve adenocarcinomas and none was shown to be familial. We report a unique example of a 41-year-old black female and her 74-year-old black mother, bot...

acanthosis nigricans (an), tripe palm (tp) and sign of lesser trelat (lt) are rare dermatoses which are often seen with malignant conditions. acanthosis nigricans occurs both on the skin and mucus membranes as velvety hyper pigmented lesions in the flexors and around the neck, or papillomatous and verrucous lesions on the lips and buccal mucosa. these para neoplastic dermatoses are generally li...

Seborrheic Keratosis is a benign skin lesion which develops from the proliferation of keratinocytes of the epidermis. There are very few case reports of seborrheic keratosis occurring over the nipple and areola. Pigmented seborrheic keratosis can be easily mistaken for malignant melanoma. Its occurrence may be associated with internal malignany (Leser-Trelat sign). We report a case of pigmented...