background: acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. leptin (lep) and leptin receptor (lepr) gene polymorphisms can increase cardiovascular risks. the aim of this study was to investigate association between the frequencies of lep and lepr gene polymorphisms and subclinical atherosclerosis in acromegalic patients. methods: forty-four ac...

The LEPR is a glycoprotein expressed mainly in hypothalamus, where it takes part in energy homeostasis and in regulation of the activity of the secretory organs. A transition mutation in this gene results in substitution of cytosine by thymine leading to the substitution of threonine by methionine in the intracellular domain of the LEPR-b isoform. This study investigated the impact of polymorph...

Genetic markers associated with meat quality may have adverse effects on reproduction performance, as shown for a variant in the leptin receptor (LEPR) gene. There is single nucleotide polymorphism (SNP) stearoyl-CoA desaturase (SCD) gene that influences monounsaturated fatty acid content of pork. Here, we investigate and combined SCD (rs80912566 T>C) LEPR (rs709596309 C>T) SNP litter size wean...

the lepr is a glycoprotein expressed mainly in hypothalamus, where it takes part in energy homeostasis and in regulation of the activity of the secretory organs. a transition mutation in this gene results in substitution of cytosine by thymine leading to the substitution of threonine by methionine in the intracellular domain of the lepr-b isoform. this study investigated the impact of polymorph...

The aim of this study was to establish the manner in which the LEPR 223, 1019, 492, and 976 gene polymorphisms influence child obesity.We performed a prospective case-control study on 264 hospitalized children from Romania (Nutrichild study) whom we divided into 2 groups: Group I -143 controls and Group II-121 obese children.The 2 groups were evaluated regarding the anthropometry (MUAC, TST, H/...

A cDNA encoding the long form of the turkey (Meleagris gallopavo) leptin receptor (LEPR) was cloned and sequenced. Turkey LEPR showed greater than 90% sequence identity at both the nucleotide and amino acid level with chicken LEPR. The LEPR gene (long form) encodes a protein of 1147 amino acids that has features similar to other LEPRs including: a signal peptide, a single transmembrane domain, ...

BACKGROUND Acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. Leptin (LEP) and Leptin Receptor (LEPR) gene polymorphisms can increase cardiovascular risks. The aim of this study was to investigate association between the frequencies of LEP and LEPR gene polymorphisms and subclinical atherosclerosis in acromegalic patients. METHODS Forty-four ac...

Irs2-mediated insulin/IGF1 signaling in the CNS modulates energy balance and glucose homeostasis; however, the site for Irs2 function is unknown. The hormone leptin mediates energy balance by acting on leptin receptor (LepR-b)-expressing neurons. To determine whether LepR-b neurons mediate the metabolic actions of Irs2 in the brain, we utilized Lepr(cre) together with Irs2(L/L) to ablate Irs2 e...

Diabetes mellitus is associated with macro- and micro-angiopathy, leading to increased risk of peripheral ischemia. In the present study, we have characterized the microvascular phenotype at the level of limb muscles and the spontaneous angiogenesis response to surgically-induced unilateral limb ischemia in a murine model of type-2 diabetes, the obese C57BL/KsOlaHsd-Lepr(db/db) mice (Lepr(db/db...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...