Irs2-mediated insulin/IGF1 signaling in the CNS modulates energy balance and glucose homeostasis; however, the site for Irs2 function is unknown. The hormone leptin mediates energy balance by acting on leptin receptor (LepR-b)-expressing neurons. To determine whether LepR-b neurons mediate the metabolic actions of Irs2 in the brain, we utilized Lepr(cre) together with Irs2(L/L) to ablate Irs2 e...

A cDNA encoding the long form of the turkey (Meleagris gallopavo) leptin receptor (LEPR) was cloned and sequenced. Turkey LEPR showed greater than 90% sequence identity at both the nucleotide and amino acid level with chicken LEPR. The LEPR gene (long form) encodes a protein of 1147 amino acids that has features similar to other LEPRs including: a signal peptide, a single transmembrane domain, ...

background: acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. leptin (lep) and leptin receptor (lepr) gene polymorphisms can increase cardiovascular risks. the aim of this study was to investigate association between the frequencies of lep and lepr gene polymorphisms and subclinical atherosclerosis in acromegalic patients. methods: forty-four ac...

Increased adiposity is a major risk factor for cardiovascular disease and NIDDM (1). Genetic determinants of the degree of adiposity and body fat distribution have been demonstrated by twin and adoption studies, and the heritability (h) of obesity has been estimated to be as high as 0.90 (2). However, the major genes underlying the heritable contribution to body fatness in humans have remained ...

The aim of this study was to establish the manner in which the LEPR 223, 1019, 492, and 976 gene polymorphisms influence child obesity.We performed a prospective case-control study on 264 hospitalized children from Romania (Nutrichild study) whom we divided into 2 groups: Group I -143 controls and Group II-121 obese children.The 2 groups were evaluated regarding the anthropometry (MUAC, TST, H/...

Genetic markers associated with meat quality may have adverse effects on reproduction performance, as shown for a variant in the leptin receptor (LEPR) gene. There is single nucleotide polymorphism (SNP) stearoyl-CoA desaturase (SCD) gene that influences monounsaturated fatty acid content of pork. Here, we investigate and combined SCD (rs80912566 T>C) LEPR (rs709596309 C>T) SNP litter size wean...

AIM To investigate the expression and immunohistochemical localization of leptin receptor (LEPR) in human periapical granulomas. METHODOLOGY Periapical inflammatory lesions were obtained from extracted human teeth and teeth which underwent periapical surgery. After their histopathological categorization as periapical granulomas (n = 20), they were examined by immunohistochemistry using human ...

The LEPR is a glycoprotein expressed mainly in hypothalamus, where it takes part in energy homeostasis and in regulation of the activity of the secretory organs. A transition mutation in this gene results in substitution of cytosine by thymine leading to the substitution of threonine by methionine in the intracellular domain of the LEPR-b isoform. This study investigated the impact of polymorph...

We have generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose expression is driven by the rat synapsin I promoter synapsin-LEPR B (SYN-LEPR-B). We have also generated mice that are compound hemizygotes for the transgenes SYN-LEPR-B and neuron-specific enolase-LEPR B (NSE-LEPR-B). We observed a degree of correction in db/db mice that are hemizygous (Syn db/db) and ho...

Despite new therapies, breast cancer continues to be the second leading cause of cancer mortality in women, a consequence of recurrence and metastasis. In recent years, a population of cancer cells has been identified, called cancer stem cells (CSCs) with self-renewal capacity, proposed to underlie tumor recurrence and metastasis. We previously showed that the adipose tissue cytokine LEPTIN, in...