نتایج جستجو برای: leca

تعداد نتایج: 225  

Journal: :Organic & biomolecular chemistry 2016
Myriam Bergmann Gaëlle Michaud Ricardo Visini Xian Jin Emilie Gillon Achim Stocker Anne Imberty Tamis Darbre Jean-Louis Reymond

The galactose specific lectin LecA partly mediates the formation of antibiotic resistant biofilms by Pseudomonas aeruginosa, an opportunistic pathogen causing lethal airways infections in immunocompromised and cystic fibrosis patients, suggesting that preventing LecA binding to natural saccharides might provide new opportunities for treatment. Here 8-fold (G3) and 16-fold (G4) galactosylated an...

2012
G Badalians Gholikandi E Dehghanifard M Noori Sepehr A Torabian S Moalej A Dehnavi AR Yari AR Asgari

BACKGROUND Water filtration units have been faced problems in water turbidity removal related to their media, which is determined by qualitative indices. Moreover, Current qualitative indices such as turbidity and escaping particle number could not precisely determine the efficiency of the media in water filtration, so defining new indices is essential. In this study, the efficiency of Anthraci...

Journal: :Archives of medical research 2006
William A Petri Omer Chaudhry R Haque Eric Houpt

The Gal/GalNAc lectin is a candidate vaccine antigen for an amebiasis vaccine due to its mediation of parasite adherence to the human intestine, because partial immunity in humans is associated with a mucosal IgA response against it, and because it is effective as a vaccine against amebic colitis in the murine model. The LecA domain of the Gal/GalNAc lectin contains neutralizing antibody epitop...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Thorsten Eierhoff Björn Bastian Roland Thuenauer Josef Madl Aymeric Audfray Sahaja Aigal Samuel Juillot Gustaf E Rydell Stefan Müller Sophie de Bentzmann Anne Imberty Christian Fleck Winfried Römer

Glycosphingolipids are important structural constituents of cellular membranes. They are involved in the formation of nanodomains ("lipid rafts"), which serve as important signaling platforms. Invasive bacterial pathogens exploit these signaling domains to trigger actin polymerization for the bending of the plasma membrane and the engulfment of the bacterium--a key process in bacterial uptake. ...

2016
Nihan Özengin Ayse Elmaci

BACKGROUND There is growing interest in the natural and constructed wetlands for wastewater treatment. While nutrient removal in wetlands has been extensively investigated, information regarding the degradation of the pharmaceuticals and personal care products (PPCPs) has only recently been emerging. PPCPs are widely distributed in urban wastewaters and can be removed to some extent by the cons...

2016
Mohammad Noori Sepehr Hossein Kazemian Esmail Ghahramani Abdeltif Amrane V. Sivasankar Mansur Zarrabi

Natural, H2O2 and MgCl2 modified Light Weight Expanded Clay Aggregate (LECA) were used as fluoride adsorbents. Characterization of LECA and its modified forms was done by infra-red, X-ray diffraction, scanning electron microscope and X-ray fluorescence studies. The specific surface area of HML and MGML was 3.34 and 3.97 times greater than that of NL (11.72 m/g). Improved chemical composition of...

Journal: :Journal of bacteriology 2000
K Winzer C Falconer N C Garber S P Diggle M Camara P Williams

In Pseudomonas aeruginosa, many exoproduct virulence determinants are regulated via a hierarchical quorum-sensing cascade involving the transcriptional regulators LasR and RhlR and their cognate activators, N-(3-oxododecanoyl)-L-homoserine lactone (3O-C12-HSL) and N-butanoyl-L-homoserine lactone (C4-HSL). In this paper, we demonstrate that the cytotoxic lectins PA-IL and PA-IIL are regulated vi...

2016
Amine M. Boukerb Aude Decor Sébastien Ribun Rachel Tabaroni Audric Rousset Loris Commin Samuel Buff Anne Doléans-Jordheim Sébastien Vidal Annabelle Varrot Anne Imberty Benoit Cournoyer

LecA and LecB tetrameric lectins take part in oligosaccharide-mediated adhesion-processes of Pseudomonas aeruginosa. Glycomimetics have been designed to block these interactions. The great versatility of P. aeruginosa suggests that the range of application of these glycomimetics could be restricted to genotypes with particular lectin types. The likelihood of having genomic and genetic changes i...

Journal: :Chemical communications 2011
Delphine Sicard Samy Cecioni Maksym Iazykov Yann Chevolot Susan E Matthews Jean-Pierre Praly Eliane Souteyrand Anne Imberty Sébastien Vidal Magali Phaner-Goutorbe

Atomic force microscopy reveals that Pseudomonas aeruginosa LecA (PA-IL) and a tetra-galactosylated 1,3-alternate calix[4]arene-based glycocluster self-assemble according to an aggregative chelate binding mode to create monodimensional filaments. Lectin oligomers are identified along the filaments and defects in chelate binding generate branches and bifurcations. A molecular model with alternat...

Journal: :Angewandte Chemie 2023

Die beiden tetravalenten Lektine LecA und LecB des ESKAPE-Erregers Pseudomonas aeruginosa sind notwendig für dessen bakterielle Adhäsion, Biofilmbildung Invasion in Wirtszellen. Sie gelten daher als Ansatzpunkte zur medikamentösen antiinfektiösen Therapie. Vor kurzem berichteten wir über hochwirksame divalente Galaktoside spezifische LecA-Inhibitoren. Diese litten jedoch unter einer sehr gering...

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