نتایج جستجو برای: ldl modification

تعداد نتایج: 156235  

Journal: :acta medica iranica 0
"mohammadi r doosti m javadi e sarrafnejad a karimi a mohagheghi a "

different classes of autoantibodies against two antigenic forms of modified low density lipoprotein (mod-ldl) were detected in 140 patients by indirect elisa method. investigated autoantibodes included total immunoglobulins (igt). immunoglobulin g (igg), and immunoglobulin m (igm) against oxidized ldl with copper ions (ox-ldl) and modified ldl with malondialdehyde (mal-ldl) (igt-o) igt against ...

2011
Naila Rabbani Lisa Godfrey Mingzhan Xue Fozia Shaheen Michèle Geoffrion Ross Milne Paul J. Thornalley

OBJECTIVE To study whether modification of LDL by methylglyoxal (MG), a potent arginine-directed glycating agent that is increased in diabetes, is associated with increased atherogenicity. RESEARCH DESIGN AND METHODS Human LDL was isolated and modified by MG in vitro to minimal extent (MG(min)-LDL) as occurs in vivo. Atherogenic characteristics of MG(min)-LDL were characterized: particle size...

Journal: :The Journal of clinical investigation 1986
S Parthasarathy S G Young J L Witztum R C Pittman D Steinberg

Previous studies have established that low density lipoprotein (LDL) incubated with endothelial cells (EC) undergoes extensive oxidative modification in structure and that the modified LDL is specifically recognized by the acetyl LDL receptor of the macrophage. Thus, in principle, EC-modified LDL could contribute to foam cell formation during atherogenesis. Oxidatively modified LDL is also pote...

MA Ghaffari MR Saffari T Ghiasvand

The oxidative modification of low density lipoprotein (LDL) may play an important role in atherogenesis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Our understanding of the mechanism of LDL oxidation and factors that determine its susceptibility to oxidation is still incomplete. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper...

Journal: :The Journal of clinical investigation 1986
J W Heinecke L Baker H Rosen A Chait

Extracellular superoxide was detected in cultures of monkey and human arterial smooth muscle cells as indicated by superoxide dismutase inhibitable reduction of cytochrome c. Superoxide production by these cells in the presence of Fe or Cu resulted in modification of low density lipoprotein (LDL). The degree of LDL modification was directly proportional to the rate of superoxide production by c...

MA Ghaffari MR Saffari T Ghiasvand

The oxidative modification of low density lipoprotein (LDL) may play an important role in atherogenesis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Our understanding of the mechanism of LDL oxidation and factors that determine its susceptibility to oxidation is still incomplete. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper...

2005
Urs P. Steinbrecher Joseph L. Witztum Sampath Parthasarathy Daniel Steinberg

The monocyte/macrophage appears to be the precursor of many of the lipid-laden cells in atherosclerotic lesions, but the mechanism by which these cells accumulate cholesterol to become foam cells remains unclear. We have previously reported that cultured endothelial cells can modify low density lipoprotein (LDL) in a manner that leads to rapid uptake by the acetyl LDL receptor of macrophages. T...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1991
I Jialal D A Freeman S M Grundy

The oxidative modification of low density lipoprotein (LDL) may provide a crucial link between plasma LDL and the atherosclerotic lesion. The studies presented herein define time-dependent modifications of LDL constituents caused by CuSO4-catalyzed oxidation. Measurement of the cholesterol content of oxidized LDL by the cholesterol esterase-oxidase assay was found to be inaccurate. The enzymati...

Journal: :iranian journal of pharmaceutical research 0
ma ghaffari mr saffari t ghiasvand

the oxidative modification of low density lipoprotein (ldl) may play an important role in atherogenesis. antioxidants that can prevent ldl oxidation may act as antiatherogens. our understanding of the mechanism of ldl oxidation and factors that determine its susceptibility to oxidation is still incomplete. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper...

Journal: :Annals of the New York Academy of Sciences 1992
M Hermann B Gmeiner

Low density lipoprotein (LDL) is known to form complexes with polysulfated compounds, like heparin, dextran sulfate (DS), and chondroitin sulfate. In particular, chondroitin 6-sulfate (C6S)-rich proteoglycans of the arterial intima can associate with LDL, resulting in accumulation of LDL in atherosclerotic lesions. Besides LDL complex formation, LDL self-aggregation has been recently suggested ...

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