background and aims: the latency-associated transcript (lat) transcribed by latent herpes simplex virus type-1 in neuron cells are able to influence their host cell pathways. while the most of previous studies were focused on anti-apoptotic effects of lat, our investigation is making an effort to explore lat potency on cell cycle pathway in neuroblastoma cell lines. methods: the evaluation of l...

herpes simplex virus type-1 (hsv-1) causes a variety of diseases in human. this virus is a neurotropic pathogen of human that establishes latent infection in the sensory ganglia innervating the site of primary infection. a number of genes including icp34.5 control hsv-1 pathogenicity and icp34.5 has been identified as hsv-1 virulence gene. open reading frame p (orf p) is also a hsv-1 gene that ...

Servando López-Aguayo, Yaroslav V. Kartashov, Victor A. Vysloukh, and Lluis Torner ICFO-Institut de Ciencies Fotoniques, and Universitat Politecnica de Catalunya, Mediterranean Technology Park, 08860 Castelldefels (Barcelona), Spain Photonics and Mathematical Optics Group, Tecnólogico de Monterrey, Monterrey México 64849 Departamento de Fisica y Matematicas, Universidad de las Americas – Puebla...

Background and Aims: The latency-associated transcript (LAT) transcribed by latent Herpes Simplex Virus type-1 in neuron cells are able to influence their host cell pathways. While the most of previous studies were focused on anti-apoptotic effects of LAT, our investigation is making an effort to explore LAT potency on cell cycle pathway in neuroblastoma cell lines. Methods: The evaluation of L...