objective: a number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. it has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (no) production. these data suggest that the cytotoxic effect of saffron extra...

the aim of this study is to determine whether there is a role of podoplanin and glutathione s-transferases t1 (gst-t1) expression in laryngeal squamous cell carcinoma. the study was completed with 33 patients and gene expression analysis was performed by qrt–pcr. the podoplanin and gst-t1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryn...

following the first report of laryngeal small cell carcinoma in canada in 1972,only 82 cases of this cancer has been reported in the literature untill 2001.this cancer originates from laryngeal neuroendocrine cells.It,s clinical presentation consists of hoarseness,breathing difficulty:and cigarette smoking is the most important risk factor.this type of cancer is mostly presented after 50 years ...

Background & Objective: Laryngeal squamous cell carcinoma (LSCC) is considered to be one of the most common cancers of the head and neck, accounting for roughly 90% of all malignant tumors of the larynx. To have a timely diagnosis for a better and practical therapy, molecular markers have to be investigated. The aim of this study was to determine the expression of Cyclin D1 (CD...

OBJECTIVE The present study was to investigate the effect of 1,25(OH)2D3 on the proliferation and apoptosis of Lscc-02 laryngeal squamous cell carcinoma cell line. METHOD Lscc-02 human laryngeal squamous cell carcinoma cell line was treated with 1,25(OH)2D3. Cell proliferation was evaluated by MTT assay, distribution of cell cycle and rate of apoptosis determined by flow cytometry, and cell m...

introduction: sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far.in the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer.   materials and methods: patients with biopsy-proven squamous cell carcinoma of the larynx were included...

BACKGROUND Recent research indicates that CD133 are expressed in several kinds of stem cells, among which, its high expression in laryngeal carcinoma has caused wide concern. To further explore efficaciously targeting drugs to laryngeal carcinoma stem cells (CSCs), we transplanted a solid tumor from CSCs into abdominal subcutaneous tissue of nude mice, and then compared the biological character...

mucoepidermoid carcinoma is a neoplasm of salivary gland origin, and its laryngeal occurrence is extremely rare. this malignant tumor is composed of two distinct cell types, the epidermoid and mucus cells. prognosis is largely dependent on the histologic pattern. in this report, an extremely rare laryngeal cancer and its clinicopathologic features are described.

Introduction: Sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far.In the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer.   Materials and Methods: Patients with biopsy-proven squamous cell carcinoma of the larynx were included...

MicroRNAs play important roles in laryngeal carcinoma and other cancers. However, the expression of microRNAs in paracancerous tissue has been studied less. Here, using laser capture microdissection (LCM), we detected the expression of microRNAs in paracancerous tissues. Among all down-regulated microRNAs in the center area of tumor tissues, only miR-30b expression was significantly reduced in ...