non-hodgkin lymphoma usually presents with generalized lymphadenopathy, but it can also involve any part of the human body. lymphomatous involvement of muscles is a rare presentation and has been reported to occur in only 1.1% in non-hodgkin lymphoma. here we, present a 32 year-old iranian man with primary involvement of spleen, bone, bone marrow and muscle, mimicking soft tissue sarcoma; core ...

a forty two years old woman with a history of bilateral breast augmentation for cosmetic reasons was presented for poor healing of the surgical site. tissue and periprosthetic fluid were removed from the wound site revealing an atypical lymphoid infiltrate. subsequently the patient developed axillary lymph adenopathy. excisional biopsy was performed. flow cytometry was non-diagnostic. she conti...

primary cutaneous anaplastic large cell lymphoma is a t-cell malignancy with atypical cd30 positive lymphocytes. pseudoepitheliomatous hyperplasia is an uncommon finding in primary cutaneous anaplastic large cell lymphoma, and may mimic squamous cell carcinoma as pseudomalignancy. careful attention of a pathologist to correct diagnosis of pseudoepitheliomatous hyperplasia and its underlying cau...

a 45-year-old female patient with a diagnosis of ulcerative colitis complicated with composite lymphoma in the spleen and para-aortic lymph node presented with a one-month history of malaise, weakness and fatigue. only mesalamine kept ulcerative colitis under control. in physical examination, splenomegaly was revealed and pancytopenia was obtained from laboratory data. computed tomography scan ...

a case of primary malignant non-hodgkin's lymphoma of the breast is reported. this is the first well-documented case of breast lymphoma in our institution and also in iran. the diagnosis of primary breast lymphoma requires the presence of lymphomatous infiltration in close ass, tissue in patients with neither previous lymphoma nor concurrent lymphoma in another site. there is no definite c...

background and objectives: epstein barr virus (ebv) is one of the members of herpesviridae family and a sub-category of gamma herpes virinae. ebv, which normally has cr2 or cd21 receptors on b-lymphocytes, has mutagenic features for them. the virus plays an important role in causing some malignant cancers. about 30% of the cases with non-hodgkin’s lymphoma are diffuse large b-cell lymphoma (dlb...

here, we report on a ten-year-old girl with chronic draining nonhealing ulcer in her neck and unilateral cervical chronic lymphadenopathy. her ulcer had poor clinical response to broad spectrum antibiotics and anti-tuberculosis treatment. she had undergone several wound biopsies with no conclusive results. she was otherwise healthy with no known underlying disease. final wound excisional biopsy...

diffuse large b-cell lymphoma is the most common type of non-hodgkin lymphoma. micrornas (mirnas) are endogenous small rna, which can regulate gene expression at the post-transcriptional level. mirna profiling has shown a great potential as novel diagnostic and prognostic biomarkers. the present study was performed at the nemazee teaching hospital (shiraz, iran) from 2011 to 2013.the aim of thi...

background and objective: approximately half of patients with diffuse large b-cell lymphoma are cured with current chemotherapy regimens. the purpose of this study was to evaluate bax and bcl2 expression and their relationship with the response to chemotherapy. materials and methods this study was a prospective analysis on 44 patients with diffuse large b-cell lymphoma. their specimens were sta...

the authors describe a case of histiocyte-rich b-cell lymphoma (hr-bcl), a variant of diffuse large b-cell lymphoma, in a 51-year-old man. the patient presented with large axillary lymphadenopathy. histopathologic and immunohistochemical examination of lymph node biopsy revealed diffuse effacement of the lymph node architecture by reactive histiocytes and neoplastic cd20 positive b cells. react...