letter to the editor

Proton pump inhibitors (PPIs) are widely prescribed drugs in daily practice. Allergic reactions, even small number of anaphylactic reactions to PPIs have been reported. Omeprazole, lansoprazole, pantoprazole, rapeprazol and esomeprazole are classified in the same group. Despite the similarity of biochemical structures among these drugs, presence of cross-reactivity between PPIs is controversial...

Although rare, anaphylactic reactions induced by proton pump inhibitors have been reported. The presence of cross-reactivity between different members of the group is not clear. We studied 9 patients with adverse reactions to omeprazole. Clinical symptoms appeared immediately in 8 patients and after 4 hours in 1. Symptoms ranged from urticaria/angioedema in 7 cases to anaphylaxis in 2 cases. Sk...

REFE REN CES Fracaroli TS, Miranda LQ, Sodré JL, Chaves M, Gripp A. Toxic epidermal necrolysis 1. induced by lansoprazole*. An Bras Dermatol. 2013;88:116-9. Chang YS. Hypersensitivity reactions to proton pump inhibitors. Curr Opin Allergy 2. Clin Immunol. 2012;12:348-53. de Vries AC, Kuipers EJ. Helicobacter pylori infection and nonmalignant diseases. 3. Helicobacter. 2010;15 Suppl 1:29-33. Sob...

introduction: lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. however, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administration...

Introduction: Lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. However, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. Therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administrati...

Protection of human and animal subjects. The authors declare that the procedures followed were in accordance with the regulations of the responsible Clinical Research Ethics Committee and in accordance with those of the World Medical Association and the Helsinki Declaration. Confidentiality of data. The authors declare that they have followed the protocols of their work centre on the publicatio...

Lansoprazole is effective in healing non-steroidal anti-inflammatory drugs induced ulcers, and antioxidant properties have been thought to play a key role in healing ulcers. We hypothesize that lansoprazole exerts a cytoprotective effect by inhibiting reactive oxygen species leakage from mitochondria and lipid peroxidation. We pretreated gastric epithelial RGM1 cells with lansoprazole and then ...

To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: control (C) group received vehicle without ulcer induction; ulcerated (U) vehicle; lansoprazole (L) 30 mg/kg/day lansoprazole; (WK15 WK30) groups WK at a dose 0.15 or 0.30 ml/kg/day, respectively. Ga...

We have investigated the mechanism of antiapoptotic and cell renewal effects of lansoprazole, a proton pump inhibitor, to protect and heal gastric mucosal injury in vivo induced by indomethacin, a non-steroidal anti-inflammatory drug (NSAID). Lansoprazole prevents indomethacin-induced gastric damage by blocking activation of mitochondrial and Fas pathways of apoptosis. Lansoprazole prevents ind...