نتایج جستجو برای: lactamase enzymes

تعداد نتایج: 137918  

Journal: :journal of medical bacteriology 0
hedroosha molla agha mirzaeie 1 food microbiology research center, tehran university of medical sciences, tehran, iran. ailar sabbaghi 1 food microbiology research center, tehran university of medical sciences, tehran, iran. mohammad mehdi soltan dallal 2 division of microbiology, department of pathobiology, school of public health, tehran university of medical sciences, tehran, iran.

background :   ampc beta lactamases play a significant role in creating resistance to third generation cephalosporins worldwide. they mostly express on chromosome of enterobacteriaceae especially escherichia coli and cause consequential problem in clinical treatment and lead to failure in diagnosis and phenotypic test recommended by clinical and laboratory standards institute.   methods : total...

ژورنال: ارمغان دانش 2019

Abstract: Introduction and objective: Resistance to β-lactam antibiotics in the clinical isolates, in most cases is caused by β-lactamase enzymes. In recent years, The incidence of broad-spectrum β-lactamase enzymes (ESBLs) among clinical isolates especially E.coli is greatly increased, since the β-lactamase have several subfamilies, using universal primers designed to detect the following comp...

2004
Rex Richards

The Gram-positive bacterium B. cereus produces both -lactamase I, a class A serine enzyme, and -lactamase II, a zinc dependent enzyme of class B. Crystallographic studies of these two enzymes have shown that -lactamase I is homologous with the penicillin-sensitive D-alaD-ala carboxypeptidase-transpeptidase of Streptomyces R61 while -lactamase II has a hitherto unknown structure. New methods of ...

رحیمی اسبوئی, بهمن, عینی, محمد ایمان, نصرالهی, محترم, پورحاجی باقر, مریم,

Background and purpose: Hospital infections are common throughout the world. Antibiotic resistance is caused after infectious diseases and hospital infections. Considering the importance of hospital infection and bacteria resistant to antibiotics, this study aimed at investigating the prevalence of β-lactamase enzymes in bacteria isolated from nosocomial infections. Material and Methods: Fi...

Journal: :Journal of infection in developing countries 2010
Supriya Upadhyay Malay Ranjan Sen Amitabha Bhattacharjee

INTRODUCTION Infections caused by Pseudomonas aeruginosa are difficult to treat as the majority of isolates exhibit varying degrees of beta-lactamase mediated resistance to most of the beta-lactam antibiotics. It is also not unusual to find a single isolate that expresses multiple beta-lactamase enzymes, further complicating the treatment options. Thus the present study was designed to investig...

اشراقیان, محمدرضا, بختیاری, روناک, حنفی ابدر, مجتبی, رستگارلاری, عبدالعزیز, سلطان‌دلال, محمدمهدی, صباغی, آیلار, فرد صانعی, عاطفه, فلاح مهرآبادی, جلیل, ملاآقامیرزایی, هدروشا,

Background: Beta- lactamase enzymes are the most important resistant factors to beta lactam antibiotics among gram negative bacteria. Nowadays, the prevalence of beta- lactamase infection is increasing worldwide and drawn the scientists attention as an important subject. Due to high prevalence of bacteria contained TEM beta lactamase and AmpC enzymes, using molecular methods especially designin...

Journal: :jundishapur journal of microbiology 0
roya rafiee department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran fereshteh eftekhar department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran; department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran. tel: +98-2129903208, fax: +98-2122431664 seyyed ahmad tabatabaei department of pediatrics, shahid beheshti university of medical sciences, tehran, ir iran dariush minaee tehrani department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran

conclusions a high prevalence of multiple β-lactamase production was observed among the ampc producers (60%), of which the majority co-produced ampc and mbl. the current study results showed correlation between β-lactamase production and the presence of antibiotic resistance genes in the isolates. results all isolates were multidrug resistant. ampc, esbl and mbl production were observed in 35 (...

Journal: :archives of clinical infectious diseases 0
hossein goudarzi department of microbiology, school of medicine, shahid beheshti university of medical sciences, tehran, ir iran arezou taherpour department of microbiology, kurdistan university of medical sciences, sanandaj, ir iran fatemeh fallah department of microbiology, school of medicine, shahid beheshti university of medical sciences, tehran, ir iran bita pourkaveh infectious diseases and tropical medicine research center, shahid beheshti university of medical sciences, tehran, ir iran soroor erfanimanesh department of microbiology, school of medicine, tehran university of medical sciences, tehran, ir iran ali hashemi department of microbiology, school of medicine, shahid beheshti university of medical sciences, tehran, ir iran; corresponding author: ali hashemi, department of microbiology, school of medicine, shahid beheshti university of medical sciences, koodakyar st., tabnak blv., yaman av., chamran highway, p. o. box: 1985717443, tehran, ir iran. tel: +98-2123872556; +98-9122947439, e-mail:

the nosocomial infections, caused by multi-drug resistant bacteria, are the most important cause of mortality throughout the world. one important mechanism against beta-lactam antibiotics is the production of beta-lactamases. enterobacteriaceae and non-fermentative bacteria, like pseudomonas aeruginosa and acinetobacter baumannnii may produce these enzymes. currently, there is no vaccine to pre...

Journal: :Antimicrobial agents and chemotherapy 1994
P A Bradford C E Cherubin V Idemyor B A Rasmussen K Bush

Ceftazidime-resistant Klebsiella pneumoniae strains began to appear when ceftazidime usage was increased in two unrelated Chicago hospitals. These strains produced a beta-lactamase with an isoelectric point of 5.6 (RP-5.6) and strong hydrolyzing activity against ceftazidime. Two different restriction digest profiles were associated with the ceftazidime resistance plasmids. A second beta-lactama...

2016
Andrew Walkty

Definitions: Beta-lactam antimicrobials are characterized by having a four-membered cyclic amide (beta-lactam ring) as part of their chemical structure (Figure 1) [1]. This broad group includes the penicillins, cephalosporins, carbapenems, and monobactams [1]. All beta-lactams have a similar mechanism of action; they inhibit bacterial cell wall synthesis [1]. Resistance to beta-lactam antimicro...

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