by late 18th or early 19th century, albino rats became the most commonly used experimental animals in numerous biomedical researches, as they have been recognized as the preeminent model mammalian system. but, the precise correlation between age of laboratory rats and human is still a subject of debate. a number of studies have tried to detect these correlations in various ways. but, have not s...

background and aims: leptin is a hormone known to control appetite and body weight. the leptin levels in obese animals are always more than animals with normal size. a wide variety of methods have been offered to treat obesity of which herbal therapy is considered as one of these methods. the aim of this study was to investigate the effect of ethanolic extract of asian red ginseng on leptin ser...

introduction: there is not much data on parasitic infections of laboratory animals that are kept in conventional conditions in iran. the present study was designed to investigate intestinal helminths infections in laboratory colonies of rats and mice. methods: droppings from 110 mice and 110 rats (each animal one dropping) belonging to experimental and breeding groups in four animal houses were...

objective: evaluation of the effects of toxoplasma gondii infection on spermatogenesis in male rats. materials and methods: the rh strain of t. gondii tachyzoites were injected interaperitoneally in an infected group of 35 rats, while 21 rats were used as controls. each ten days from 10- 70 days of post-infection (pi), 5 rats from infected group and 3 rats from control group were scarified. t...

Background and objectives: Apiaceae family is one of the largest plant families with wide distribution all around the world. The genus Hippomarathrum has 28 species around the world among them H. microcarpum is outspread in the north, northwest, west and central of Iran, and also Turkey, Caucasus and Iraq. In a previous study, two coumarins (osthole and isoimp...

results results showed that dex 1 significantly increased, while dex 30 and groups treated with zinc 10 mg/kg and zinc 20 mg/kg decreased total immobility time as compared to that of saline group. also there was a significant decrease of total immobility time when zinc administered to rats already received dex 1, compared with that of control group. conclusions the current study findings sugges...

introduction: in the present study, the effects of light cure on wound healing of mice’s skin with complete thickness were studied. materials and methods: forty male mice of nmri race were placed randomly into two groups of examination and control. under aseptic and unconscious conditions, a circular wound of 6 mm width with complete thickness of skin was made on the back of each mice. the surg...

Based on an analysis of recent scientific studies, a Technical Panel of the U.S. Environmental Protection Agency's (EPA) Risk Assessment Forum recently advised EPA risk assessors against using information on certain male rat renal tubule tumors to assess human risk under conditions specified in a new Forum report. Risk assessment approaches generally assume that chemicals producing tumors in la...