Based on the crystal structure of human DNA ligase I complexed with nicked DNA, computer-aided drug design was used to identify compounds in a database of 1.5 million commercially available low molecular weight chemicals that were predicted to bind to a DNA-binding pocket within the DNA-binding domain of DNA ligase I, thereby inhibiting DNA joining. Ten of 192 candidates specifically inhibited ...

Based on the crystal structure of human DNA ligase I complexed with nicked DNA, computer-aided drug design was used to identify compounds in a database of 1.5 million commercially available low molecular weight chemicals that were predicted to bind to a DNA-binding pocket within the DNA-binding domain of DNA ligase I, thereby inhibiting DNA joining. Ten of 192 candidates specifically inhibited ...

We argue that there exists a problem of adverse selection in the provision of advertising which makes it impossible to establish direct markets for it. The media are regarded as intermediaries that can channel advertising and allocate it efficiently by screening consumers. This role of media may result in excessive quality and prices of media products. These distortions will be more severe if c...

This paper investigates whether and to what extent there is a conflict of interest between artists and their publishers, regarding to whether and to what degree illegal distributions of their copyrighted recordings should be prevented. This conflict arises because artists also earn their profit from other market activities such as giving live performances, in addition to their share of profits ...

This paper studies, theoretically and experimentally, the effects of overconfidence fake news on information aggregation quality democratic choice in a common-interest setting. We show that exacerbates adverse widespread misinformation (i.e., news). then analyze richer models allow for partisanship, targeted intended to sway public opinion, signals correlated across voters (due media ownership ...

The Ashburner model for the hormonal control of polytene chromosome puffing has provided a strong foundation for understanding the basic mechanisms of steroid-regulated gene expression (Cold Spring Harbor Symp. Quant. Biol. 38 (1974) 655). According to this model, the steroid hormone 20-hydroxyecdysone (referred here as ecdysone) directly induces the expression of a small set of early regulator...

Mistakes and overconfidence in detecting lies could help spread. Participants our experiments observe videos which senders either tell the truth or lie, are incentivized to distinguish between them. We find that participants fail detect lies, but overconfident about their ability do so. use these findings study determinants of sharing its effect on lie detection, finding even when share truthfu...

Economists have long been puzzled by event-ticket underpricing: underpricing reduces revenue for the performer and encourages socially wasteful rent-seeking ticket brokers. What about using an auction? This paper studies introduction of auctions into this market Ticketmaster in mid-2000s. By combining primary-market auction data from with secondary-market resale value eBay, we show that Ticketm...

US education policy encourages the use of computers and the Internet at both the college level and the K-12 level. As a consequence, students have had better access to technologies to illicitly share copyrighted music and divert sales from the traditional music store retail channel. Using a panel of counties over the 1994-2004 period, I find evidence that the number of music stores fell when K-...

Many important economic questions hinge on the extent to which new goods either crowd out or complement consumption of existing products. Recent methods for studying new goods rule out complementarity by assumption, so their applicability to these questions has been limited. I develop a new model that relaxes this restriction, and use it to study competition between print and online newspapers....