The interdomain instability of single-chain fragment variable (scFv) might result in intermolecular aggregation and loss of function. In the present study, we stabilized H4-an anti-aflatoxin B(1) (AFB(1)) scFv-with an interdomain disulfide bond and studied the effect of the disulfide bond on antibody affinity. With homology modeling and molecular docking, we designed a scFv containing an interd...

The rapid release from a double-compressed tablet containing theophylline as a core drug with the pH-dependent water-soluble polymers, Eudragit L100, S100 or L100-55 used as a wall material was suppressed by argon plasma-irradiation due to an effect of inter-segmental cross-link reactions on the decrease in the surface polymer solubility of outer layer. In addition, the rapid theophylline relea...

INTRODUCTION Losartan is an angiotensin II receptor blocker indicated for treatment of hypertension. It also inhibits platelet agreggation through blockade of thromboxane A2/ prostaglandin H2 receptors, and has a uricosuric effect We determined the effect on ambulatory blood pressure (ABP) of 100 mg losartan monotherapy (L100) versus 50 mg losartan/12.5 mg hydrochlorothiazide (HCTZ) combination...

Gelatin-eudragit L100 nanoparticles of wet size range 170-563nm were prepared by two step dissolvation method and the effect of different concentrations of eudragit L100 and emulsifying agent sodium lauryl sulphate (SLS) on the particle size were studied. Synthesized nanoparticles were characterized by attenuated total reflectance-fourier transform infrared spectroscopy (ATRFTIR) and the mean s...

During the dissolution of cocrystal particles, solution-mediated phase transformation (SMPT) can occur either on particle surface (PS-SMPT) or in bulk solution (BP-SMPT). In this study, we compared effect various polymers PS-SMPT and BP-SMPT for first time using carbamazepine saccharine (CBZ-SAC) as a model drug. Polyethylene glycol 6000 (PEG), polyvinylpyrrolidone K-30 (PVP), hydroxypropyl met...

In this study, an attempt was made to deliver pantoprazole in a sustained manner using delayed release tablets. The tablets were prepared by the wet granulation method using HPMC, cassava starch and polyvinyl pyrrolidine as polymers, Avicel PH 102 (MCC) as filler and potato starch as binder. The prepared tablets were evaluated for hardness, mass variation, friability and drug content uniformity...

We calculate the ultrasonic attenuation in magnetic fields for spin-triplet superconducting states with line nodes vertical or horizontal relative to the RuO 2 planes. For rotating in-plane field H(θ) the attenuation α(θ) exhibits variations of fourfold symmetry in the rotation angle θ. In the case of vertical nodes, the transverse T100 sound mode yields the weakest (linear) H and T dependence ...

Introduction Collagen is the most abundant protein in the mammalian anatomy, manifesting itself in a wide variety of forms, functions, and types. In biological systems, collagen fibers provide the major mechanical support for cell attachment, thus developing the shape and form of tissues1. Collagen is used as scaffolding material in tissue engineering, but must first be characterized for mechan...