background: natural products have gained importance recently for the treatment of obesity and its complications, partly because of the side effects of modern drugs.hence, we aimed to study and compare the effect of varying concentrations of momordicacharantiaon adipogenesis and adipolysis using 3t3-l1 pre-adipocyte cell lines. methods: 3t3-l1 pre-adipocytes were procured from the national cente...

acute lymphoblastic leukemia (all) is a malignant disorder of lymphoid precursor cells, which could be classified according to morphological and cytochemical methods as well as immunophenotyping. twenty patients with all, who had been referred to the children's medical center hospital, during the year 2007, were enrolled in this study in order to evaluate the morphologic and immunophenotypic pr...

Background: Natural products have gained importance recently for the treatment of obesity and its complications, partly because of the side effects of modern drugs.Hence, we aimed to study and compare the effect of varying concentrations of Momordicacharantiaon adipogenesis and adipolysis using 3T3-L1 pre-adipocyte cell lines. Methods: 3T3-L1 pre-adipocytes were procured from the National Ce...

BACKGROUND Clinical trials of immune checkpoints modulators, including both programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) inhibitors, have recently shown promising activity and tolerable toxicity in pre-treated NSCLC patients. However the predictive role of PD-L1 expression is still controversial. This pooled analysis aims to clarify the association of clinical objec...

BACKGROUND Sarcomas consist of both tumor and stromal cells, and the interaction between these compartments is critical for tumor progression and metastasis. Tumor-derived factors may alter the differentiation capacity of the adjacent stromal cells. The aim of this study was to elucidate the paracrine impact of liposarcoma cells on pre-adipocytes, their adipogenic differentiation process and mi...

This study was conducted to evaluate the cultural contents and cultural elements represented in Vision (I & II) and Pre-University English (I & II). This study also aimed at determining if there were significant differences between these series in terms of cultural content and cultural element representation. To this end, the two ELT coursebook series were selected and analyzed based on Cortazz...

The programmed cell death-1(PD-1)/PD-ligand 1 (PD-L1) pathway is critical to immune homeostasis by promoting regulatory T (Treg) development and inhibiting effector T (such as Th17) cell responses. However, the association between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance has not been fully investigated in pre-eclampsia (PE). In this study, we observed an inverse correlation between th...

Expression of programmed cell death receptor ligand 1 (PD-L1) has been shown to be up-regulated in some gastric cancer patients and to correlate with the density of tumour infiltrating lymphocytes (TILs). However, conflicting results have been reported regarding TILs and the expression of PD-L1 as a prognostic marker for gastric cancer. We investigated the correlation of PD-L1 and TILs expressi...

This study was conducted to evaluate the cultural contents and cultural elements represented in Vision (I & II) and Pre-University English (I & II). This study also aimed at determining if there were significant differences between these series in terms of cultural content and cultural element representation. To this end, the two ELT coursebook series were selected and analyzed based on Cortazz...