PReS-FINAL-2337: The eurofever registry: 3 years of enrollment S Federici, J Frenkel, S Ozen, PRINTO and Eurofever Project, J Antòn, PRINTO and Eurofever Project, JI Arostegui, F De Benedetti, P Dolezalova, H Girschick, V Hentgen, M Hofer, H Lachmann, I Koné-Paut, J Kuemmerle-Deschner, B Neven, H Ozdogan, C Rose, A Simon, S Stojanov, N Toplak, I Touitou, R Vesely, P Woo, C Wouters, N Ruperto, A...

Matthias Baumann ⁎, Mutlu Ozdogan , Tobias Kuemmerle , Kelly J. Wendland , Elena Esipova , Volker C. Radeloff a a Department of Forest and Wildlife Ecology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI 53706-1598, USA b Geography Department, Humboldt University Berlin, Unter den Linden 6, 10099 Berlin, Germany c Earth System Analysis, Potsdam Institute for Climate Impact Rese...

Neumann, W., C. Levers, F. Widemo, N. J. Singh, P. G. M. Cromsigt, and T. Kuemmerle. 2022. Hunting as land use: Understanding the spatial associations among hunting, agriculture, forestry. Ecology Society 27(1):2. https://doi.org/10.5751/ES-12882-270102

We have previously shown that endogenous Insulin-like growth factor-I (IGF-I) regulates growth of human intestinal smooth muscle cells by stimulating proliferation and inhibiting apoptosis. In active Crohn’s disease, expression of IGF-I and the αVβ3 integrin receptor ligands, fibronectin and vitronectin are increased. The aim of the present study was to determine whether occupation of the αVβ3 ...

Ca 2+ release from the sarcoplasmic reticulum (SR) via the ryanodine receptor (RyR) regulates both general cellular activities such as metabolism and more specific events such as smooth muscle contraction. RyR opening is itself promoted by Ca 2+ (Endo et al., 1970; Fabiato, 1983) and decreased by FK506 binding proteins (FKBPs) (Brillantes et al., 1994; Xin et al., 2002). Among other substances,...

Murthy, K. S., J. R. Grider, J. F. Kuemmerle, and G. M. Makhlouf. Sustained muscle contraction induced by agonists, growth factors, and Ca mediated by distinct PKC isozymes. Am J Physiol Gastrointest Liver Physiol 279: G201–G210, 2000.—The role of protein kinase C (PKC) in sustained contraction was examined in intestinal circular and longitudinal muscle cells. Initial contraction induced by ago...

Kuemmerle, John F. Endogenous IGF-I regulates IGF binding protein production in human intestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 278: G710– G717, 2000.—Human intestinal smooth muscle in culture produces insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3, IGFBP-4, and IGFBP-5, which modulate the effects of IGF-I. This study examined the regulation o...

Background Hyper-IgD Syndrome/Mevalonate Kinase Deficiency (HIDS/MKD) is a rare autoinflammatory disease caused by defect in the gene encoding mevalonate kinase. Treatment with interleukin-1β inhibitor canakinumab (CAN, approved since 2017 for HIDS/MKD) resulted rapid remission most patients, both controlled trials and clinical practice. Objectives The present study investigates long-term effic...

Background The Interleukin-1 (IL-1) mediated systemic autoinflammatory diseases (SAIDs), including the cryopyrin-associated periodic syndromes (CAPS), tumor necrosis factor receptor-associated syndrome (TRAPS), mevalonate kinase deficiency (MKD), and of IL-1 receptor antagonist (DIRA) belong to a group rare immunodysregulatory that primarily present in early childhood with variable multiorgan i...