نتایج جستجو برای: ktp

تعداد نتایج: 715  

Journal: :Veterinary journal 2016
Heather K Knych Rick M Arthur Stacy Steinmetz Dan S McKemie

Ketoprofen (KTP) is currently only available as an injectable formulation for intravenous administration to horses. The primary goal of the study reported here was to characterize the pharmacokinetics of KTP, including determination of bioavailability following oral administration of the currently available injectable formulation as well as a paste formulation. KTP was administered intravenousl...

Journal: :Veterinary journal 2003
P Lees P M Taylor F M Landoni A K Arifah C Waters

The non-steroidal anti-inflammatory drug ketoprofen (KTP) was administered as the racemate to cats intravenously (IV) and orally at clinically recommended dose rates of 2 and 1 mg/kg, respectively, to establish its chiral pharmacokinetic and pharmacodynamic properties. After IV dosing, clearance was more than five times greater and elimination half-life and mean residence time were approximatel...

2011
MMB Ribeiro A Pinto M Pinto M Heras I Martins A Correia E Bardaji I Tavares M Castanho

BACKGROUND AND PURPOSE Kyotorphin (KTP; L-Tyr-L-Arg), an endogenous neuropeptide, is potently analgesic when delivered directly to the central nervous system. Its weak analgesic effects after systemic administration have been explained by inability to cross the blood-brain barrier (BBB) and detract from the possible clinical use of KTP as an analgesic. In this study, we aimed to increase the li...

Journal: :Journal of neurochemistry 2009
Huidi Jiang Yongjun Hu Richard F Keep David E Smith

L-Kyotorphin (L-KTP), an endogenous analgesic neuropeptide, is a substrate for aminopeptidases and a proton-coupled oligopeptide transporter, PEPT2. This study examined the CSF efflux, antinociceptive response, and hydrolysis kinetics in brain of L-KTP and its synthetic diastereomer D-kyotorphin (D-KTP) in wild-type and Pept2 null mice. CSF clearance of L-KTP was slower in Pept2 null mice than ...

2016
Sónia Sá Santos Sara M. Santos Antónia R. T. Pinto Vasanthakumar G. Ramu Montserrat Heras Eduard Bardaji Isaura Tavares Miguel A. R. B. Castanho

Chronic brain ischemia is a prominent risk factor for neurological dysfunction and progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral common carotid artery occlusion (2VO) causes a progressive neurodegeneration in the hippocampus, learning deficits and memory loss as it occurs in AD. Kyotorphin (KTP) is an endogenous antinociceptive dipeptide whose role ...

2016
Juliana Perazzo Miguel A. R. B. Castanho Sónia Sá Santos

The endogenous peptide kyotorphin (KTP) has been extensively studied since it was discovered in 1979. The dipeptide is distributed unevenly over the brain but the majority is concentrated in the cerebral cortex. The putative KTP receptor has not been identified yet. As many other neuropeptides, KTP clearance is mediated by extracellular peptidases and peptide transporters. From the wide spectru...

Journal: :Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2013
Carolyn A Coughlan Sunil P Verma

OBJECTIVE The KTP laser has become commonplace in transoral head and neck surgery. The interactions of this laser with commonly used supplies in transoral surgery have not been formally examined. This study evaluates the effects of the KTP laser on surgical supplies. STUDY DESIGN Experimental study. SETTING The study was conducted in an empty operating room at a university-affiliated medica...

Journal: :The Laryngoscope 2006
Vaclav Pavelec Pavel Polenik

OBJECTIVES The aim of this study was to compare the effectiveness of the Er,Cr:YSGG (Waterlase) laser with KTP and CO2 lasers in laser assisted uvulopalatoplasty (LAUP) for treatment of snoring. STUDY DESIGN This is a prospective study of 63 patients who were treated for snoring by LAUP either with Er,Cr:YSGG (n = 21) or with KTP (n = 21) or CO2 lasers (n = 21). Histologic analysis was perfor...

In this work,the physical properties of  KTP and RTP single-crystals have been investigated by performing accurate total energy calculations in the framework of density functional theory by using the full-potential linearized augmented plane wave method. The effects of Rb substitution on structural, electronic and optical properties of KTP are discussed. The structural properties have been calc...

Journal: :JAMA otolaryngology-- head & neck surgery 2013
Chi-Te Wang Tsung-Wei Huang Li-Jen Liao Wu-Chia Lo Mei-Shu Lai Po-Wen Cheng

IMPORTANCE Vocal polyps are common exophytic laryngeal lesions that usually necessitate microscopic laryngeal surgery under general anesthesia. Office-based indirect laryngoscopic procedures provide an alternative management option and can be performed comfortably under flexible endoscopic guidance. Combining angiolytic potassium titanyl phosphate (KTP) laser treatment and flexible endoscopic p...

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