conclusions this epidemiological study indicated different rates and transmission risks for these viruses. hcv was the most contagious viral infection and htlv-i was the weakest in the prisoners. apart from kshv infection which its prevalence was as twice as in the general population, the prevalence of hbv and htlv-i in prisoners was nearly in ranges of the general population. background prison...

patients and methods in the present cross-sectional study, 109 patients with established hiv infection, who visited a governmental and referral center for hiv screening in tehran (tehran west health center (twhc)) between may 2014 and july 2015 were enrolled according to the convenience sample strategy. after peripheral blood collection, isolation of plasma and peripheral blood mononuclear cell...

Lymphomas in people living with HIV (PLWH) are associated Epstein Barr virus (EBV) and Kaposi-sarcoma-associated herpesvirus (KSHV). They include primary effusion lymphoma, large B-cell lymphoma arising multicentric Castleman disease, plasmablastic Burkitt diffuse Hodgkin (HL). Inclusion of these lymphomas the WHO classification tumors hematopoietic lymphoid tissues increasing recognition disor...

El KSHV / HHV-8 está asociado con el sarcoma de Kaposi (KS), así como trastornos linfoproliferativos, principalmente en pacientes infección por VIH SIDA. Aunque la asociación entre linfomas y se ha descrito, presencia simultánea las 2 entidades dentro del mismo órgano es rara asocia Presentamos un caso aparición linfoma angioinmunoblástico linfonodo, además concurrente herpes virus (KSHV) Epste...

Since Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) was first identified in Kaposi's sarcoma (KS) lesions of HIV-infected individuals with AIDS, the basic biological understanding of KSHV has progressed remarkably. However, the absence of a proper animal model for KSHV continues to impede direct in vivo studies of viral replication, persistence, and pathogenesis. In resp...

Kaposi's sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the host following an acute infection. Reactivation from latency contributes to the development of KSHV-induced malignancies, which include Kaposi's sarcoma (KS), the most common cancer in untreated AIDS patients, primary effusion lymphoma and multicentric Castleman's disease. However, the physiological cues that t...

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). Most tumor cells in these malignancies are latently infected by KSHV. Thus, viral latency is critical for the development of tumor and induction of tumor-associated angiogenesis. KSHV encodes more than two dozens of miRNAs bu...

Soon after the discovery of Kaposi sarcoma (KS)-associated herpesvirus (KSHV), it was appreciated that this virus was associated with most cases of multicentric Castleman disease (MCD) arising in patients infected with human immunodeficiency virus. It has subsequently been recognized that KSHV-MCD is a distinct entity from other forms of MCD. Like MCD that is unrelated to KSHV, the clinical pre...

Lytic induction of latent Kaposi's sarcoma-associated herpesvirus (KSHV) has been considered as a therapeutic option for efficient treatment of several KSHV-associated malignancies. Here, we developed a robust high-throughput screening system that allows an easy and quantitative measurement of lytic induction of latent KSHV and discovered three anthracyclines as potent inducers from screen of F...

Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a virus that appears to be involved in the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas, encodes a G protein-coupled receptor (KSHV-GPCR) that exhibits constitutive signaling. In this report, we show that two chemokines, interleukin 8 (IL-8) and growth-related protein-alpha, activate KSHV-GPCR over constituti...