Epithelial ovarian cancer is one of the most lethal gynecologic cancers and the fifth most frequent cause of female cancer deaths in the United States. Despite dramatic treatment successes in other cancers through the use of molecular agents targeted against genetically defined events driving cancer development and progression, very few insights into epithelial ovarian cancer have been translat...

Temporal patterning is an important aspect of embryonic development, but the underlying molecular mechanisms are not well understood. Drosophila neuroblasts are an excellent model for studying temporal identity: they sequentially express four genes (hunchback --> Kruppel --> pdm1 --> castor) whose temporal regulation is essential for generating neuronal diversity. Here we show that hunchback --...

To identify biologically functional regions in the product of the Drosophila melanogaster gene Kruppel, we cloned the Kruppel homolog from Drosophila virilis. Both the previously identified amino (N)-terminal repression region and the DNA-binding region of the D. virilis Kruppel protein are greater than 96% identical to those of the D. melanogaster Kruppel protein, demonstrating a selective pre...

Neurogenesis in Drosophila and mammals requires the precise integration of spatial and temporal cues. In Drosophila, embryonic neural progenitors (neuroblasts) sequentially express the transcription factors Hunchback, Kruppel, Pdm1/Pdm2 (Pdm) and Castor as they generate a stereotyped sequence of neuronal and glial progeny. Hunchback and Kruppel specify early temporal identity in two posterior n...

Kruppel-like factor 4 (KLF4) is a member of the KLF family of transcription factors and regulates proliferation, differentiation, apoptosis and somatic cell reprogramming. KLF4 is also a tumor suppressor in certain cancers. KLF4 can be an indicator of stem-like capacity in embryonic stem cells (ESCs) and mesenchymal stem cells (MSCs), etc. The KLF4 gene is conserved in chimpanzee, Rhesus monkey...

kruppel-like factors (klfs) are a highly related zinc-finger family of transcription factors implicated inthe regulation of the eukaryotic cellular growth and differentiation of a diverse set of cells in mammal. usingrt-pcr technique, a 456 bp cdna fragment encoding n-terminus part of a klf2b was isolated from the skinmucosa of common carp (cyprinus carpio) using two degenerative oligonucleotid...

Mukhopadhyay D, Jain MK. Inhibition of VPF/VEGF-mediated angiogenesis by the Kruppel-like factor KLF2. J Biol Chem 2005;280:28848–28851. 26. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, LaManna JC, Jain MK. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1{alpha} expression and function in the endothelium. J Biol Chem 2009;284: 20522–20530. 27. Urbich C...

OBJECTIVE Protein inhibitor of activated signal transducer and activator of transcription-1 (PIAS1) is known to function as small ubiquitin-like modifier (SUMO) E3 ligase as well as transrepressor. The aim of the study is to elucidate the regulatory mechanisms for these 2 different functions, especially with respect to endothelial inflammation. METHODS AND RESULTS The mitogen-activated protei...