نتایج جستجو برای: klotho protein

تعداد نتایج: 1235788  

Background and Objectives: Different diets have important roles in human health and aging. In the current study, we aimed to characterize the Klotho, an anti-aging protein, gene expression and protein level in the serum and assess the protein levels of Transforming growth factor-β and Platelet-derived growth factor in old rats which treated with different diets (high-fat, high-protein, low calo...

ژورنال: پژوهش در پزشکی 2017

Background: The present study aimed to examine the effect of aerobic training on Klotho protein, interleukin-6 and tumor necrosis factor alpha inflammatory factors in rats. Materials and Methods: For this purpose 12 male rats with an average weight 170g±5g and the age of eight weeks were divided into two groups: control (N= 6) and experimental (N= 6) groups. The experimental groups trained o...

Davoudi, Negin, Nabatchian, Fariba,

Klotho is an anti-aging single-pass membrane protein that is mainly produced in the kidney. The level of soluble klotho decreases with age and the klotho gene is associated with an increased risk of age-related diseases, such as diabetes, skin atrophy, chronic kidney disease, ataxia and cancer. The klotho gene is composed of five exons and encodes a membrane glycoprotein located in the plasma ...

Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training. Materials and Met...

Journal: :Kidney & blood pressure research 2014
Ahmad Almilaji Mentor Sopjani Bernat Elvira José Borras Miribane Dërmaku-Sopjani Carlos Munoz Jamshed Warsi Undine E Lang Florian Lang

BACKGROUND/AIMS The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of Klotho protein could function as an enzyme with e.g. β-glucuronidase activity, be cleaved off and be released into blood and cerebrospinal fluid. Klotho regulates several cellular transporters. Klotho protein deficiency accelerates the appearance of age related disord...

Background: The percentage of elderly people is growing in our country. Aging is associated with multiple diseases, disabilities and heavy medical expenses. The new multi-functionalProtein, Klotho, not only reduces the aging process but also affects several diseases associated with older ages.The aim of this study was to evaluate the effect of vitamin D supplements on the plasma levels of kloth...

Journal: :بینا 0
رعنا سرخابی r sorkhabi tabriz university of medical sciences, tabriz, iranدانشگاه علوم پزشکی تبریز امیر قربانی حق جو a ghorbani haghju tabriz university of medical sciences, tabriz, iranدانشگاه علوم پزشکی تبریز علی کیاور a kiavar tabriz university of medical sciences, tabriz, iranدانشگاه علوم پزشکی تبریز

purpose: to investigate the levels of klotho and endothelin-1(et-1) in plasma and aqueous humor in patients with pseudoexfoliation syndrome (pes). methods: fifteen individuals with pes and 15 age-matched subjects without pes who were scheduled for cataract extraction participated in the study. samples of aqueous humor and peripheral blood were taken in the operating room just before cataract su...

2013
Ahmad Almilaji Carlos Munoz Tatsiana Pakladok Ioana Alesutan Martina Feger Michael Föller Undine E. Lang Ekaterina Shumilina Florian Lang

Klotho, a transmembrane protein, which can be cleaved off as β-glucuronidase and hormone, is released in both, kidney and choroid plexus and encountered in blood and cerebrospinal fluid. Klotho deficiency leads to early appearance of age-related disorders and premature death. Klotho may modify transport by inhibiting 1,25(OH)2D3 formation or by directly affecting channel and carrier proteins. T...

2015
Ao Bian Javier A Neyra Ming Zhan Ming Chang Hu

Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging suppressor through a wide variety of mechanisms, s...

Journal: :JCI insight 2017
Rik Mencke Geert Harms Jill Moser Matijs van Meurs Arjan Diepstra Henri G Leuvenink Jan-Luuk Hillebrands

Klotho is a renal protein involved in phosphate homeostasis, which is downregulated in renal disease. It has long been considered an antiaging factor. Two Klotho gene transcripts are thought to encode membrane-bound and secreted Klotho. Indeed, soluble Klotho is detectable in bodily fluids, but the relative contributions of Klotho secretion and of membrane-bound Klotho shedding are unknown. Rec...

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