نتایج جستجو برای: kiss1r protein

تعداد نتایج: 1234772  

2017
Alexandra Blake Magdalena Dragan Rommel G. Tirona Daniel B. Hardy Muriel Brackstone Alan B. Tuck Andy V. Babwah Moshmi Bhattacharya

Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2). TNBC patients lack targeted therapies, as they fail to respond to endocrine and anti-HER2 therapy. Prognosis for this aggressive cancer subtype is poor and survival is limited due to the development of resistance to available chemotherapies...

2013
Donna Cvetković Andy V. Babwah Moshmi Bhattacharya

Kisspeptins (KP), peptide products of the kisspeptin-1 (KISS1) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISS1R). KISS1R couples to the Gαq/11 signaling pathway. KISS1 is a metastasis suppressor gene and the KP/KISS1R signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers. On the other hand, recent studies indicate that...

2015
Mehri Fayazi Michele Calder Moshmi Bhattacharya George A. Vilos Stephen Power Andy V. Babwah

BACKGROUND Expression of kisspeptin (protein) and Kiss1r (mRNA) was recently documented in the mouse uterus on D4 of pregnancy (the day of embryo implantation) suggesting that the uterine-based kisspeptin (KP)/kisspeptin receptor (KISS1R) signaling system regulates embryo implantation. Despite this important suggestion, it was never demonstrated that the uterus actually exhibits a functional KP...

2012
Judith E Cartwright Paula Juliet Williams

Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy. Roles indicated for kisspeptin in pregnancy include regulating trophoblast invasion and migration during placentation. The pregnancy-specific disorder pre-eclampsia (PE) is now accepted to begin with inadequate trophoblast invasion and the curren...

Journal: :Cancer research 2011
Sung-Gook Cho Ying Wang Melissa Rodriguez Kunrong Tan Wenzheng Zhang Jian Luo Dali Li Mingyao Liu

Activation of KISS1 receptor (KISS1R or GPR54) by its ligands (Kisspeptins) regulates a diverse function both in normal physiology and pathophysiology. In cancer, KISS1R has been implicated in tumor angiogenesis and metastasis, but a broader evaluation of KISS1R in tumorigenesis and tumor progression is yet to be conducted. In this study, we used mouse models of Kiss1r gene knockout and mouse m...

Journal: :Endocrinology 2012
Jyothis T George Stephanie B Seminara

The hypothalamic hormone GnRH is a central driver of pituitary gonadotropin secretion, controlling pulsatile gonadotropin secretion, modulating gonadal steroid feedback, and bringing about full fertility in the adult. Thus, understanding GnRH neuronal regulation is essential to understanding the neurohumoral control of human reproduction. Genetic tools were used in patients with GnRH deficiency...

Journal: :international journal of endocrinology and metabolism 0
mandana mahmoodzadeh sagheb department of biology, kazeroon branch, islamic azad university, kazeroon, ir iran; department of biology, kazeroon branch, islamic azad university, kazeroon, ir iran. tel/ fax: +98-7116474331 negar azarpira transplant research center, shiraz university of medical sciences, shiraz, ir iran ramin yaghobi transplant research center, shiraz university of medical sciences, shiraz, ir iran

background: leptin and adiponectin are the two key metabolic hormones secreted from adipocytes to control food intake and energy expenditure. the action of both hormones in regulation of gonadotropin releasing hormone (gnrh) secretion from the hypothalamus is mediated through kisspeptins. kisspeptins are products of kiss-1 gene. leptin and adiponectin are modulators of kiss-1 expression in the ...

Journal: :Neuroendocrinology 2015
Robert P Millar Andy V Babwah

Kisspeptin (KP) is now well recognized as a potent stimulator of gonadotropin-releasing hormone (GnRH) secretion and thereby a major regulator of the neuroendocrine-reproductive axis. KP signals via KISS1R, a G protein-coupled receptor (GPCR) that activates the G proteins Gαq/11. Modulation of the interaction of KP with KISS1R is therefore a potential new therapeutic target for stimulating (in ...

Journal: :The Journal of clinical investigation 2014
Kristen P Tolson Christian Garcia Stephanie Yen Stephanie Simonds Aneta Stefanidis Alison Lawrence Jeremy T Smith Alexander S Kauffman

The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons, KISS1R is expressed in other brain areas and peripheral tissues, which suggests that kisspeptin has additional functions beyond reproduction. Here, we studied the energetic and metabolic phenotype in mice lacking kisspep...

Journal: :In vivo 2012
A Makri P Msaouel C Petraki D Milingos A Protopapas A Liapi A Antsaklis C Magkou M Koutsilieris

BACKGROUND The KISS1/KISS1R system has been implicated in the physiology of reproduction and many studies have documented the stimulatory effect of kisspeptin on Gonadotropin-releasing Hormone (GnRH) and gonadotropin secretion. In addition, the KISS1/KISS1R system has been implicated in several pathophysiological processes, including cancer. MATERIALS AND METHODS We examined the pattern of KI...

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