نتایج جستجو برای: kiss1 receptor

تعداد نتایج: 590816  

Journal: :molecular and biochemical diagnosis (journal) 2014
hamidreza vaziri zahra sayar roya faraji

background: the kiss peptins and its receptor g protein coupled receptor (gpr54) or kiss1 receptor system are being described as key signaling molecules for reproductive function in animal models and humans. they play essential roles in regulation of the hypothalamic- pituitary- gonadal (hpg) axis and the onset of puberty and fertility. objective: this study was performed to delineate the assoc...

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2016
Rebecca Gresham Shengyun Li Daniel A Adekunbi Minghan Hu Xiao Feng Li Kevin T O’Byrne

The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the posterodorsal subnucleus of the medial amygdala (MePD). We hypothesised that Kiss1 in the MePD may have an influence on male sexual behavior. To test this we...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Satoshi Ogawa Fatima M Nathan Ishwar S Parhar

Kisspeptin, a neuropeptide encoded by the KISS1/Kiss1, and its cognate G protein-coupled receptor, GPR54 (kisspeptin receptor, Kiss-R), are critical for the control of reproduction in vertebrates. We have previously identified two kisspeptin genes (kiss1 and kiss2) in the zebrafish, of which kiss1 neurons are located in the habenula, which project to the median raphe. kiss2 neurons are located ...

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Journal: :Endocrinology 2007
Risto Lapatto J Carl Pallais Dongsheng Zhang Yee-Ming Chan Amy Mahan Felecia Cerrato Wei Wei Le Gloria E Hoffman Stephanie B Seminara

The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice demonstrate hypogonadotropic hypogonadism, but until recently, the phenotype of Kiss1 knockout mice was unknown. This report describes the reproductive phenotypes of mice carrying targeted deletions of Kiss1 or Gpr54 on the s...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Junko Tomikawa Yoshihisa Uenoyama Makiko Ozawa Tatsuya Fukanuma Kenji Takase Teppei Goto Hitomi Abe Nahoko Ieda Shiori Minabe Chikaya Deura Naoko Inoue Makoto Sanbo Koichi Tomita Masumi Hirabayashi Satoshi Tanaka Takuya Imamura Hiroaki Okamura Kei-ichiro Maeda Hiroko Tsukamura

This study aims to determine the epigenetic mechanism regulating Kiss1 gene expression in the anteroventral periventricular nucleus (AVPV) to understand the mechanism underlying estrogen-positive feedback action on gonadotropin-releasing hormone/gonadotropin surge. We investigated estrogen regulation of the epigenetic status of the mouse AVPV Kiss1 gene locus in comparison with the arcuate nucl...

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Journal: :Endocrine-related cancer 2007
Didier Marot Ivan Bieche Chantal Aumas Stéphanie Esselin Céline Bouquet Sophie Vacher Gwendal Lazennec Michel Perricaudet Frederique Kuttenn Rosette Lidereau Nicolas de Roux

KiSS1 is a putative metastasis suppressor gene in melanoma and breast cancer-encoding kisspeptins, which are also described as neuroendocrine regulators of the gonadotropic axis. Negative as well as positive regulation of KiSS1 gene expression by estradiol (E(2)) has been reported in the hypothalamus. Estrogen receptor alpha (ERalpha level is recognized as a marker of breast cancer, raising the...

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Journal: :Endocrines 2022

The kisspeptin system includes the cleavage products Kiss1 precursor and receptor (Kiss1R). It was originally discovered studied in cancer metastasis, but identification of KISS1/KISS1R gene mutations causing hypogonadotropic hypogonadism (HH) revealed unexpected effects reproduction. Nowadays, is main central gatekeeper reproductive axis at puberty adulthood, it also has a widespread functiona...

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Journal: :Endocrinology 2013
Simina M Popa Ryutaro M Moriyama Claudia S Caligioni Jasmine J Yang Caroline M Cho Tessa L Concepcion Amy E Oakley In Hae Lee Elisenda Sanz Paul S Amieux Alain Caraty Richard D Palmiter Victor M Navarro Yee-Ming Chan Stephanie B Seminara Donald K Clifton Robert A Steiner

Kisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction. Animals lacking functional genes for either kisspeptin or its receptor exhibit low gonadotropin secretion and infertility. Paradoxically, a recent study reported that genetic ablation of nearly all Kiss1-expressing neurons (Kiss1 neurons) does not impair reproduction, arguing t...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Renata Frazão Roberta M Cravo Jose Donato Dhirender V Ratra Deborah J Clegg Joel K Elmquist Jeffrey M Zigman Kevin W Williams Carol F Elias

Reproductive function requires timely secretion of gonadotropin-releasing hormone, which is controlled by a complex excitatory/inhibitory network influenced by sex steroids. Kiss1 neurons are fundamental players in this network, but it is currently unclear whether different conditions of circulating sex steroids directly alter Kiss1 neuronal activity. Here, we show that Kiss1 neurons in the ant...

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Journal: :Advances in experimental medicine and biology 2013
Shinji Kanda Yoshitaka Oka

The kisspeptin system is considered to be essential for successful mammalian reproduction. In addition to the Kiss1 peptide, Kiss2, the product of kiss2 (the kiss1 paralogue), has also been shown to activate kisspeptin receptor signaling pathways in nonmammalian species. Furthermore, in nonmammalian species, there are two subtypes of receptors, Gpr54-1 (known as GPR54 or Kiss1R in mammals) and ...

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