background: infertility is an increasing medical and social problem. in vitro fertilization (ivf) has become a common and accessible treatment for a wide variety of indications that have variable outcomes. natural killer (nk) cells have been identified as relevant immunological factors involved in reproductive success or failure. objective: the aim of this study was to compare the percentage of...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...

background: pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the salvia officinalis on the uterine natural killer cells population in the pregnant mice that needs to be investigated. objective: the aim of this study was to determine the effect of the ethanolic extract of the salvia officinalis on the uterine natural killer ...

The effect of natural killer (NK) cells and lymphokine activated killer ( LAK) cells was studied on a group of human melanoma cell lines. Peripheral blood from healthy volunteers was utilized as a fresh source of natural killer cells and rhI L-2 for producing LAK cells. The cytotoxicity of effector cells was quantified using a 4 hour SI determining the density of antigen expression on tumor...

background: chronic fatigue syndrome (cfs) is a complex condition involving severe fatigue and disabling musculoskeletal and cognitive symptoms. we reported that 6, 12 and 24 months following infectious mononucleosis (im), 13%, 7% and 4% of adolescents, respectively, met criteria for cfs. whether endocrinologic or immunologic dysfunction accompanies cfs is unclear. objectives: to determine if s...

Background: Pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the Salvia officinalis on the uterine Natural Killer cells population in the pregnant mice that needs to be investigated. Objective: The aim of this study was to determine the effect of the ethanolic extract of the Salvia officinalis on the uterine Natural Kill...

the effect of natural killer (nk) cells and lymphokine activated killer ( lak) cells was studied on a group of human melanoma cell lines. peripheral blood from healthy volunteers was utilized as a fresh source of natural killer cells and rhi l-2 for producing lak cells. the cytotoxicity of effector cells was quantified using a 4 hour si determining the density of antigen expression on tumor cel...

the cytotoxic activity of natural killer cells is usually tested by radioactive assay csi cr release assay), which detects the release of cytoplasmic contents after plasma membrane disintegration of dying cells. in contrast to this indirect evaluation of cytotoxicity, the assessment of cell damage by flow cytometry aims to provide a more exact characterization of the death pathway via detection...

Background:  Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules.  These receptors could induce signals that determine NK cells ability to mediate cytotoxicity.  Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective:  To evaluate the influence of sHLA and two monoclonal an...