نتایج جستجو برای: killer cell immunoglobulin like receptor
تعداد نتایج: 2606499 فیلتر نتایج به سال:
host genetic factors play a central role in determining the clinical phenotype of human diseases. association between two polymorphic loci in human genome, human leukocyte antigen (hla) and killer cell immunoglobulin-like receptors (kirs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. hence, defining the influence of genetic di...
study of kir expression and hla ligands in cd56+ lymphocytes of drug resistant tuberculosis patients
analysis of receptor–ligand interactions in the context of diseases necessitates to understand how hla–kir genotypes function in diseases. although cd56+ lymphocytes are derived from multiple lineages, they share a functional association with immunosurviellance and antimicrobial responses. the present study aimed to determine whether kir phenotype in cd56 lymphocytes and corresponding...
Investigation of the KIR-status of patients with head and neck squamous-cell carcinoma in bloodserum
Introduction The activation of natural killer cells (NK) by their KIR (killer cell immunoglobulin-like receptor) is a potent defense system tumor cells. In this thesis we want to investigate the profile 16 inhibiting and activating KIRs in bloodserum patients with head neck squamous-cell carcinoma (HNSCC). Furthermore, calculate correlation between KIR-status overall survival (OS) HNSCC-patients.
The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte...
INTRODUCTION During discussion at the WHO Nomenclature Committee for Factors of the HLA System meeting in Victoria, Canada, in May 2002, it was decided to form a subcommittee to coordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors (KIRs) [1]. These genes are encoded on chromosome 19 (19q13.4) and have varying degrees of polymorphism. The receptors...
Background : Allogeneic hematopoietic stem cells transplantation (HSCT) is a valuable therapy for refractory acute leukemias, leukemias with a high risk for relapse, myelodysplastic syndromes, and chronic myeloid leukemia. HSCT outcome is dependent on several factors, including the stage of disease, degree of human leukocyte antigen (HLA) identity between donor and recipient, conditioning regim...
HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine substitution at position 47 (I47V) of the inhib...
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